About: Application of biophysical methods in biotechnological and clinical praxis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IBS5004107
Description	The cooperation between three laboratories of the Institute of Biophysics proceeding from the knowledge of the physical principles of interactions of nucleis acids and model compounds with metal surfaces and with ligands (tumor supresor p53, cytostatics) will be further developed. The cooperation will be aimed on the one hand to the development of a biosensor for detection of DNA damage and detection of the binding of ligand to DNA, on the other hand to the development of new cytostatics based on cis-Pt with a higher antitumor activity and lower mutagenic effect. New results can be expected especially due to the interconnection of the research at the physical, electrochemical and molecular biological levels, leading to publications in high quality international journals. The subject of the proposed project is up-to-date as it follows from the interests of manufacturers and their direct involvement in the project. (en) Bude rozvíjena spolupráce tří laboratoří BFÚ AV ČR, která bude vycházet z poznatků fyzikálních principů interakcí nukleových kyselin a modelových sloučenin s povrchy kovů a s ligandy (nádorový supresor p53, cytostatika). Spolupráce bude směřovat jednak ke konstrukci biosenzoru pro detekci poškození DNA a pro detekci její vazby s ligandy, jednak k vývoji nových cytostatik na basi cis-platiny, která budou mít lepší protinádorovou aktivitu a sníženou mutagenní činnost. Nové výsledky přinese zejména propojení výzkumu na úrovni fyzikální, elektrochemické a molekulárně biologické. Projekt je založen na rozvinuté domácí i zahraniční spolupráci, jejímž výsledkem je řada publikací v prestižních mezinárodních časopisech. Aktuálnost navrhované problematiky vyplývá ze zájmu o přímé zapojení výrobních podniků v projektu.
Title	Application of biophysical methods in biotechnological and clinical praxis (en) Aplikace biofyzikálních metod v biotechnologické a klinické praxi
skos:notation	IBS5004107
http://linked.open...avai/cep/aktivita	Scheme of targeted research and development support
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IBS5004107/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IBS5004107/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2006-06-19 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	33638382
http://linked.open...ai/cep/hlavniObor	BO - Biofyzika
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cep/klicovaSlova	DNA absorption;two-dimensional condensation;electrode double layer;electrochemical impedance;voltammetry;p53 protein;tumor suppressor;cytostatics;cisplatin;biosensor;DNA damage;DNA interactions;supercolied DNA;superhelix density (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	46 (xsd:int)
http://linked.open...enychVysledkuVRIV	46 (xsd:int)
http://linked.open...okUkonceniPodpory	2005
http://linked.open...okZahajeniPodpory	2001
http://linked.open...iciPoslednihoRoku	2006
http://linked.open...atUdajeProjZameru	2006
http://linked.open.../vavai/cep/soutez	SAV0-SS2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	EI - Biotechnologie a bionika CG - Elektrochemie
http://linked.open...jektu+dodavatelem	2D condensation of bases and nucleosides takes place at solid polycrystalline amalgam surfaces. Electrochemical method enables sensitive detection of oligonucleotides length. Properties of DNA modified by antitumor analogues of cisplatinum were described (en) 2D kondenzace bazí a nukleosidů nastává také na pevných polykrystalických amalgamových površích. Elektrochemická metoda umožňuje citlivou detekci délky oligonukleotidů. Byly popsány vlastnosti DNA modifikované analogy protinádorově účinné cisplatiny. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	cisplatin DNA damage biosensor cytostatics electrochemical impedance voltammetry tumor suppressor DNA interactions DNA absorption electrode double layer p53 protein supercolied DNA two-dimensional condensation
is http://linked.open...vavai/riv/projekt of	DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent Detection of phase transients in two-dimensional adlayers of adenosine at the solid amalgam electrode surfaces Microanalysis of DNA by stripping transfer voltammetry Effects of low-frequency magnetic fields on the viability of yeast Saccharomyces cerevisiae Effects of 50 Hz magnetic fields on the viability of different bacterial strains. Determination of picogram quantities of oligodeoxynucleotides by stripping voltammetry at mercury modified graphite electrode surfaces Electrochemical properties of nucleic acid components. Electrochemical detection of interactions of echinomycin with DNA at mercury film electrodes (MFE). Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides. Application of avidin-biotin technology and adsorptive transfer stripping square-wave voltammetry for detection of DNA hybridization and avidin in transgenic avidin maize. On the adsorption kinetics of phase transients of adenosine at the different carbon electrodes modified with a mercury layer On the adsorption and kinetics of phase transients of adenosine at the different carbon electrodes modified with a mercury layer. Microanalysis of oligodeoxynucleotides by cathodic stripping voltammetry at amalgam-alloy surfaces in the presence of copper ions. Biofyzika na prahu 2.tisíciletí. Effect of the low-frequency magnetic fields on the living organisms Effect of pH and substituents on the two-dimensional condensation of cytosine DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand Effect of the low-frequency magnetic fields on the living organisms DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. Effect of electromagnetic fields on the denitrification activity of Paracoccus denitrificans Co je biofyzika ? Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes Label-free determination of picogram quantities of DNA by stripping voltammetry with solid copper amalgam or mercury electrodes in the presence of copper. On the formation kinetics of two-dimensional cytidine films. Structure and stability of cytidine adlayers na Au(111) , carbon electrodes with thin film of mercury (MFE) a Hg electrode. Study of interactions of nucleic acids with modified electrodes surfaces by electrochemical impedance spectroscopy. Chiral discrimination in platinum anticancer drugs. Electrochemical impedance spectroscopy of polynucleotide adsorption. volution of electrochemical methods - from virtual possibilities to virtual instruments. Electrochemical properties of surface active compounds. Effects of low-frequency magnetic fields on bacteria Escherichia coli. Electrochemical sensors for DNA interactions and damage. Electrochemical analysis of nucleic acids. Interaction of DNA with echinomycin at the mercury electrode surface as detected by impedance and chronopotentiometric measurements. Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes. Impedance measurements of nucleic acids. Impedace Measurements of Nucleic Acids and Self - Assembled Lavers of Their Components Impedance measurements of nucleic acids and self-assembled layers of their components. Application of mercury thin film electrodes in electrochemical analysis Voltammetric behavior of DNA modified with osmium tetroxide 2,2'-bipyridine at mercury electrodes Low-frequency magnetic field effect on cytoskeleton and chromatin Thin film mercury electrodes in electrochemical analysis of the nucleic acids and their componends Application of thin film mercury electrodes and solid amalgam electrodes in electrochemical analysis of the nucleic acids components: detection of the two-dimensional phase transients of adenosine Comparison of the low-frequency magnetic field effects on bacteria Escherichia coli, Leclercia adecarboxylata and Staphylococcus aureus Comparison of the low-frequency magnetic field effects on bacteria Escherichia coli, Leclercia adecarboxylata and Staphylococcus aureus
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IBS5004107/2001/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IBS5004107/2002/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IBS5004107/2003/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IBS5004107/2004/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IBS5004107/2005/ico%3A68081707

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