About: DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand.

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About: DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The global modification of DNA by novel platinum compounds, trans-[PtCl2(NH3)(Am)], where Am = 2-methylbutylamine or sec-butylamine was investigated in cell-free media. The results showed that the replacement of one ammine group by 2-methylbutylamine or sec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA. The global modification of DNA by novel platinum compounds, trans-[PtCl2(NH3)(Am)], where Am = 2-methylbutylamine or sec-butylamine was investigated in cell-free media. The results showed that the replacement of one ammine group by 2-methylbutylamine or sec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA. (en)
Title	DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. (en)
skos:prefLabel	DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand. (en)
skos:notation	RIV/68081707:_____/04:17033296!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	1097;1109
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(IBS5004107), P(KJB5004301), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Marini Palomeque, María Victoria Prokop, Radim
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	560963
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/04:17033296
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; transplatin; antitumor drugs (en)
http://linked.open.../riv/klicoveSlovo	antitumor drugs cisplatin transplatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E27829D5DBDA]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Application of biophysical methods in biotechnological and clinical praxis Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Pizarro, A. M. Prokop, Radim Marini, Victoria Navarro-Ranninger, C.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0006-2952
number of pages	13 (xsd:int)

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