About: TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Rezistence některých nádorových buněk k působení TRAILu je hlavní překážkou terapeutického využití tohoto cytokinu. Velkým přínosem v léčbě by mohla být kombinovaná terapie využívající látky schopné zcitlivět nádorové buňky k účinkům TRAILu. Mezi ně může patřit kyselina docosahexaenová. V naší studii jsme prokázali posílení buněčné smrti při současné aplikaci TRAILu a DHA a zabývali se příslušnými mechanismy. (cs) The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis. The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis. (en)
Title	TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death TRAIL a kyselina docosahexaenová kooperují při indukci smrti nádorových buněk tlustého střeva HT-29 (cs) TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death (en)
skos:prefLabel	TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death TRAIL a kyselina docosahexaenová kooperují při indukci smrti nádorových buněk tlustého střeva HT-29 (cs) TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death (en)
skos:notation	RIV/68081707:_____/05:00024400!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany	43;48
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/03/0766), P(GA524/04/0895), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Vaculová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	547023
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/05:00024400
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRAIL; DHA; cell death (en)
http://linked.open.../riv/klicoveSlovo	DHA cell death TRAIL
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C7AFF77A9F27]
http://linked.open...i/riv/nazevZdroje	Cancer letters
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of the cell death induced by dietary lipid components and endogenous apoptotic regulators in colon epithelial cells Modulation of proliferation, differentiation and apoptosis of hemopoietic cells - interactions of cytokines, drugs and lipid nutrition compounds
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	229
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Hofmanová, Jiřina Kozubík, Alois Vaculová, Alena
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0304-3835
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death

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