About: Center of Integrated Genomics

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=LN00A079
Description	The proposed Center of Genomics is created to enable collaboration of top laboratories in various aspects of genomics with the aim to fully develop the field of integrated genomics not existing in the Czech Republic. The Center would serve asa methodical base and a center for education of graduate students. Individual collaborating research groups have knowledge and technical equipment for developing specialized parts of genomics.Large-scale DNA sequencing (of eg. bacterial genomes) is well established and basic tools of bioinformatics are available. Development of chip technology, including the SAGE method, is of particular importance. Mammalian functional genomics is realizedat the level of positional cloning of genes for sterility, imprinting, eye development, hypertension and mitochondrial diseases. The Center will elaborate complex genomics methodology and apply it to biomedical and biotechnology projects. (en) Navrhuje se vytvoření Centra genomiky, jež unožní spolupráci předních laboratoří tak, aby se plně rozvinul v ČR dosud neexistující obor integrované genomiky. Centrum by bylo metodickou základnou genomiky,školícím pracovištěm zejména doktorandů a garantem rozvoje oboru v ČR. Jednotlivé spolupracující řešitelské skupiny mají zkušenosti a metodické i přístrojové zázemí v určitých výsecích genomiky. Je zajištena sekvenace velkých úseků DNA(např. bakteriálních genomů), k dispozici jsou základní nástroje bioinformatiky. Mimořádně důlezité je rozvíjení čipové technologie včetne metody SAGE. Savčí funkční genomika je rozvíjena na úrovni pozičního klonování genu sterility,imprintingu, vývoje oka, hypertenze a mitochondriálních chorob. Centrum bude rozvíjet komplexní metodologii genomiky a bude ji aplikovat v biomedicínských a biotechnologických projektech jak uvedeno v návrhu.
Title	Center of Integrated Genomics (en) Centrum integrované genomiky
skos:notation	LN00A079
http://linked.open...avai/cep/aktivita	Research centres
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/LN00A079/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/LN00A079/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2008-05-28 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1757899
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cep/klicovaSlova	genomics; SAGE; pozitional cloning; bioremodiatiton (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	145 (xsd:int)
http://linked.open...enychVysledkuVRIV	145 (xsd:int)
http://linked.open...okUkonceniPodpory	2004
http://linked.open...okZahajeniPodpory	2000
http://linked.open...iciPoslednihoRoku	2005
http://linked.open...atUdajeProjZameru	2005
http://linked.open.../vavai/cep/soutez	SMSM0031008
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CE - Biochemie
http://linked.open...jektu+dodavatelem	Hlavní výsledky činnosti Centra jsou: globální charakterizace genové exprese samčích pohlavních buněk na myším modelu a identifikace genu pro lidskou familiární juvenilní nefropatii. (cs) Major achievements are: global characterization of mouse male sperm cells gene expression and identification of the gene responsible for human familiar juvenile nephropathy. (en)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	genomics SAGE pozitional cloning
is http://linked.open...vavai/riv/projekt of	Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutations Developmental changes of cytochrome c oxidase and citrate synthase in rat heart homogenate Cubozoan jellyfish: an Evo/Devo model for eyes and other sensory systems Genetic Defects of Cytochrome c Oxidase Assembly Hereditary disorders of mitochondrial ATP synthase GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene FUNCTIONS OF PROTEASE DOMAINS IN M-PMV HERVd: the Human Endogenous Retrovirus Database: update Genetic analysis of X-linked hybrid sterility in the house mouse Mitochondrial Membrane Potential and ATP Production in Primary Disorders of ATP Synthase Mitochondrial diseases and ATPase defects of nuclear origin Mason-Pfizer monkey virus matrix protein - the structural study Long-term reinfection of the human genome by endogenous retroviruses Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat Positional cloning of the Hybrid sterility 1 gene: fine genetic mapping and evaluation of two candidate genes Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order Gag domains of Mason-Pfizer monkey virus mediating assembly of capsids and %22core related%22 particles in bacteria. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat Congenital Disorders of Glycosylation Type Ia: Clinical, Biochemical and Molecular Analyses in Two Siblings with Cerebellar Hypoplasia Degradation of juvenile hormone analog by soil microbial isolates. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4 Cloning and developmental expression of amphioxus Dachshund INFLUENCE OF CYSTEINE RESIDUES ON THE ACTIVITY OF THE PROTEASE OF MASON-PFIZER MONKEY VIRUS. INTERACTION OF ENVELOPE GLYCOPROTEINS WITH MATRIX PROTEIN OF MASON-PFIZER MONKEY VIRUS INTERACTION OF ENVELOPE GLYCOPROTEINS WITH MATRIX PROTEIN OF MASON-PFIZER MONKEY VIRUS Isolation and characterization of the Mason-Pfizer monkey virus p12 protein The impact of the altered polyprotein ratios on the capsid assembly and infectivity of Mason-Pfizer monkey virus The influence of assembly conditions on effeiciency and morphology of in vitro assembled capsid-like particles formed from CA-NC of Mason-Pfirzer money virus The investigation of the capsid assembly and infectivity of Mason-Prizer Monkey virus frame-shift mutants Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity SPEEDING UP OF THE ASSIGNMENT OF BACKBONE RESONANCES OF WILD-TYPE MATRIX PROTEIN FROM M-PMV Study of retrovirus capsid formation Aktivity komplexů dýchacího řetězce v izolovaných trombocytech A single V317A or V317M substitution in Enzyme II of a newly identified beta-glucoside phosphotransferase and utilization system of Corynebacterium glutamicum R extends its specificity towards cellobiose. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome The foot soldiers of science. Nontuberculous mycobacteria in patients with cystic fibrosis: Exoperience of the Prague CF centre. Accumulation of homoplasmic mtDNA point mutations in erythroblasts isolated from the bone marrow of patients with refractory anemia with ring sideroblasts (RARS) Acute hyperammonaemic encephalopathy in a female newborn caused by a novel, de novo mutation in the ornithine transcarbamylase gene A reorientation of helical domains of the matrix protein from Mason-Pfizer monkey virus caused by a single point mutation A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model Energy metabolism of adipose tissue - Physiological aspects and target in obesity treatment Eucaryotic operon genes can define highly conserved syntenies The European dimension for the mouse genome mutagenesis Omega-3 PUFA of Marine Origin Limit Diet-Induced Obesity in Mice by Reducing Cellularity of Adipose Tissue Reductive activation of Cr(VI) by nitric oxide synthase Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases QF-PCR Examination of Parental and Meiotic Origin of Trisomy 21 in Central and Eastern Europe Topology of Chromosomes 18 and X in Human Blastomeres from 3- to 4-Day-old Embryos Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochrome c oxidase due to the mtDNA 2bp microdeletion of TA at positions 9205 and 9206 The Mouse SAGE Site: database of public mouse SAGE libraries Plasma levels of 7-hydroxylated dehydroepiandrosterone(DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer´s disease and vascular dementia Polymorphisms in the mannose binding lectin gene affect the cystic fibrosis pulmonary phenotype Plasmid pA81 from chlorobenzoate degrading strain Achromobacter xylosoxidans A8 Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations Differential cytokine profile in children with cystic fibrosis A large-scale study of the random variability of a coding sequence: a study on the CFTR gene Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta - oxidation in white fat Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae: inhibition with peptidomimetic inhibitors. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Activities of cytochrome c oxidase and citrate synthase in lymphocytes of obese and normal-weight subjects

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