About: Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order     Goto   Sponge   NotDistinct   Permalink

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Description
  • Pomocí metody SAGE (sériová analýza genové exprese) byly vytvořeny genové expresní profily celých varlat dospělých myší kmene C57BL/6J. Byla provedena podrobná bioinformatická analýza SAGE transkriptomů celkového varlete a veřejně dostupných SAGE transkriptomů somatických buněk varlete a dalších sedmi somatických tkání. Geny exprimované v tkáních varlete vykazují nenáhodné uspořádání mezi autozomy a X chromozomem a také tendenci tvořit poziční klastry na chromozomech. Výsledky poskytují nový důkaz ve prospěch teorie o akumulaci samčích genů na X chromozomu v somatických buňkách varlete a ukazují protichůdné působení meiotické X inaktivace v germinálních buňkách varlete. (cs)
  • Gene expression profiles of total testis of adult C57BL/6J mice were generated using serial analysis of gene expression (SAGE). An extensive bioinformatic analysis of the total testis SAGE transcriptome and publicly available SAGE transcriptomes of testicular somatic cells and seven non-testis tissues was performed. The genes expressed in testicular tissues exhibited non-random distribution between autosomes and the X chromosome as well as certain tendency to form positional clusters on chromosomes. The results provide new evidence in favor of the theory of male-biased genes accumulation on the X chromosome in testicular somatic cells and indicate the opposite action of the meiotic X-inactivation in testicular germ cells.
  • Gene expression profiles of total testis of adult C57BL/6J mice were generated using serial analysis of gene expression (SAGE). An extensive bioinformatic analysis of the total testis SAGE transcriptome and publicly available SAGE transcriptomes of testicular somatic cells and seven non-testis tissues was performed. The genes expressed in testicular tissues exhibited non-random distribution between autosomes and the X chromosome as well as certain tendency to form positional clusters on chromosomes. The results provide new evidence in favor of the theory of male-biased genes accumulation on the X chromosome in testicular somatic cells and indicate the opposite action of the meiotic X-inactivation in testicular germ cells. (en)
Title
  • Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order
  • Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order (en)
  • Globální transkriptomová analýza varlat myší C57BL/6J metodou SAGE: průkaz nenáhodného uspořádání genů (cs)
skos:prefLabel
  • Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order
  • Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order (en)
  • Globální transkriptomová analýza varlat myší C57BL/6J metodou SAGE: průkaz nenáhodného uspořádání genů (cs)
skos:notation
  • RIV/68378050:_____/05:00021168!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 29;45
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(KSK5052113), P(LN00A079), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 522783
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/05:00021168
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • SAGE; testis; gene expression (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [BC3C21DA2890]
http://linked.open...i/riv/nazevZdroje
  • B M C Genomics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Forejt, Jiří
  • Pačes, Václav
  • Vlček, Čestmír
  • Strnad, Petr
  • Divina, Petr
http://linked.open...n/vavai/riv/zamer
issn
  • 1471-2164
number of pages
is http://linked.open...avai/riv/vysledek of
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