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| Description
| - In contrast to the CNS environment, the peripheral nerves of mammals provide cellular and extracellular conditions supporting the regeneration of axons. The supporting conditions originate distal to the point of injury during Wallerian degeneration that results in formation of immature Schwann cells. The cells restore the production of molecules which promote axonal regrowth. The synthesis of axon-promoting molecules by Schwann cells and suitable content of their extracellular matrix are important extrinsic factors influencing the axon regeneration in the peripheral nervous systém. Some recent reports suggest that the cellular and extracellular environment is probably not the same for regeneration of motor and somatosensory axons in the peripheralnerves. In addition, formation of different extrinsic cues supporting the axonal regeneration of the motor and somatosensory axons in the damaged peripheral nerves as well as the ventral and dorsal spinal roots of the rats. The spatial-temporal changes o (en)
- V periferních nervech savců může na rozdíl od CNS probíhat regenerace axonů. Vnější podmínky pro regeneraci axonů se tvoří v poškozeném periferním nervu během Wallerovy degenerace, kdy vzniklé nediferencované Schwannovy buňky syntetizují molekuly stimulující růst axonů. Obnovená syntéza těchto molekul společně s vhodným složením extracelulární matrix jsou hlavní vnější faktory, které ovlivňují regeneraci axonů v periferní nervové soustavě. Dosavadní poznatky naznačují, že v poškozeném nervu nemusbýt celulární a molekulární podmínky pro regeneraci motorických a somatosenzorických axonů stejné; navíc, další rozdíly lze očekávat při srovnání podmínek pro regeneraci axonů distálně od místa přerušení spinálních kořenů a periferního nervu. Cílem projektu je srovnat celulární a extracelulární podmínky pro regeneraci motorických a somatosenzorických axonů, které vznikají po přerušení kořenů spinálních nervů a periferních nervů u laboratorního potkana. Celulární a extracelulární podmínky pro
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| Title
| - Cellular and extracellular environment for the axon regeneration following injury of the spinal roots and peripheral nerves (en)
- Celulární a extracelulární prostředí pro regeneraci axonů při kořenových a distálních lezích periferních nervů
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open.../cep/klicovaSlova
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...jektu+dodavatelem
| - Přínos tkví v upřesnění a zdařilém znázornění komponent extracelulární matrix , Schwannových buněk a složek kapilární stěny, jednak v dorzálních a ventrálních kořenech míšních, jednak v periferním nervu (n. femoralis) laboratorního potkana. Autoři objevi (cs)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Extrinsic endoneurial cues for sorting of regenerated sensory and motor axons in the peripheral nervous system
- Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding a61 integrin receptor
- Immunohistochemical labelling of components of the endoneurial extracellular matrix of intact and rhizotomized dorsal and ventral spinal roots of the rat - a quantitative evaluation using image analysis
- Are resident laminin molecules of the extracellular matrix needed for Schwann cell migration?
- Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy.
- Expression of integrin chains for laminin in the Schwann cells migrating into the freeze-injured dorsal root ganglia of the rat - an immunohistochemical study
- IMMUNOHISTOCHEMICAL AND IMMUNOGOLD ANALYSIS OF LAMININS IN THE PERIPHERAL NERVE STRUCTURES
- IMMUNOHISTOCHEMICAL DIFFERENCES IN THE ECM CONTENT ALONGSIDE AFFERENT AND MOTOR AXONS IN RELATION TO THE POSITION OF THE DORSAL ROOT GANGLION
- Migrating Schwann cells support the endoneurium of acellular nerve segment by laminins, fibronectin, thrombospondin, and chondroitin sulfate
- Migrating Schwann cells support the endoneurium of freeze-treated nerve segment by laminins, fibronectin, thrombospondin, and chondroitin sulfate.
- Reinnervation of the rat biceps brachii muscle through the cellular and acellular nerve grafts introduced into the ventral horn of the spinal cord
- A QUANTITATIVE IMMUNOFLUORESCENCE ANALYSIS OF SOME ECM MOLECULES AND NEUROTROPHINS ALONGSIDE AFFERENT AND MOTOR AXONS IN THE DORSAL AND VENTRAL SPINAL ROOTS
- A quantitative immunohistochemical study of the endoneurium in the rat dorsal and ventral spinal roots
- Computer-assisted quantitative immunohistochemistry of the extracellular matrix in the dorsal and ventral spinal roots with the use of a Lucia software
- Quantitative immunofluorescence for BDNF, NGF, and NT-3 in Schwann cells of the spinal roots and peripheral nerve
- Immunofluorescence staining of the insulin-like growth factor-I in the ventral and dorsal spinal roots
- Schwann cells migrating in absence of the axons in the basal lamina tubes express immunoreactivity for laminins, fibronectin, thrombospondin, and chondroitin sulfate
- Schwann cells migrating in absence of the axons in the basal lamina tubes express immunoreactivity for laminins, fibronectin, thrombospondin, and chondroitin sulfate
- Computer-assisted quantitative immunohistochemistry of the extracellular matrix in the dorsal and ventral spinal roots with the use of a lucia software
- Schwann cells and endoneurial extracellular matrix molecules as potential cues for sorting of regenerated axons: A review
- Immunohistochemical differences in the ECM content alongside afferent and motor axons in relation to the position of the dorsal root ganglion
- Immunohistochemical and immunogold analysis of laminins in the peripheral nerve structures
- Immunohistochemical analysis of some ECM components in the nerve outgrowth regenerating through the knitted tubes
- Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis
- Changes of immunofluorescence staining for ECM molecules in the satellite cells of rat dorsal root ganglia following a chronic constriction injury of the peripheral nerve
- Quantitative immunofluorescence for BDNF, NGF and NT-3 in Schwann cells of the spinal roots and peripheral nerve.
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| is http://linked.open...vavai/cep/projekt
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