About: Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy.

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About: Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Disconnection of the peripheral axonal branch from the target tissue results in changes of GFAP expression in the satellite cells of the dorsal root ganglia (DRG) and their proliferation The loss of DRG neurons was also described after the peripheral axotomy. No results are available about the reaction of DRG neurons and their satellite cells to the central axotomy. We have investigated proliferation and apoptosis in the adult rat DRG after central and peripheral axotomy. Female rats were operated for the central axotomy and peripheral axotomy. The animals were perfused through ascending aorta with phosphate-buffered saline followed Zamboni's fixative solution after 2, 4, and 6 weeks. Cryostat sections through affected and intact DRG were incubated for immunohistochemical identification of BrdU as well as apoptosis (TUNEL). Both peripheral and central axotomy stimulated proliferation of many satellite cells while apoptosis was observed in lower amount of the cells. Disconnection of the peripheral axonal branch from the target tissue results in changes of GFAP expression in the satellite cells of the dorsal root ganglia (DRG) and their proliferation The loss of DRG neurons was also described after the peripheral axotomy. No results are available about the reaction of DRG neurons and their satellite cells to the central axotomy. We have investigated proliferation and apoptosis in the adult rat DRG after central and peripheral axotomy. Female rats were operated for the central axotomy and peripheral axotomy. The animals were perfused through ascending aorta with phosphate-buffered saline followed Zamboni's fixative solution after 2, 4, and 6 weeks. Cryostat sections through affected and intact DRG were incubated for immunohistochemical identification of BrdU as well as apoptosis (TUNEL). Both peripheral and central axotomy stimulated proliferation of many satellite cells while apoptosis was observed in lower amount of the cells. (en)
Title	Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy. Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy. (en)
skos:prefLabel	Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy. Immunohistochemical study of proliferation and apoptosis in the dorsal root ganglia after supraspinal and infraspinal axotomy. (en)
skos:notation	RIV/00216224:14110/00:00002597!RIV/2002/GA0/141102/N
http://linked.open.../vavai/riv/strany	14
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/00/0407), Z(MSM 141100001)
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Hradilová Svíženská, Ivana Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	713169
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/00:00002597
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	spinal ganglia, TUNEL, apoptosis, axotomy (en)
http://linked.open.../riv/klicoveSlovo	apoptosis TUNEL axotomy spinal ganglia
http://linked.open...ontrolniKodProRIV	[72522750D11C]
http://linked.open...v/mistoKonaniAkce	Praha
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Sborník lékařský
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and extracellular environment for the axon regeneration following injury of the spinal roots and peripheral nerves
http://linked.open...UplatneniVysledku	2000
http://linked.open...iv/tvurceVysledku	Dubový, Petr Klusáková, Ilona Svíženská, Ivana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2000-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Karlova v Praze
http://localhost/t...ganizacniJednotka	14110

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