About: Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis

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About: Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The extracellular matrix formed in a knitted prosthesis, which was applied between the stumps of a transected sciatic nerve of the rat, was investigated to find out whether it provided suitable conditions for nerve regeneration. After 6 weeks, the prosthesis contained a nerve outgrowth connecting the nerve stumps. The immunohistochemical staining of the cryostat sections through the middle of the nerve prosthesis revealed that thrombospondin, fibronectin, chondroitin sulfate A and C, and type IV collagen were localised in the connective tissue surrounding the nerve outgrowth, in the perineurium of individual minifascicles, as well as in the endoneurium among regenerated nerve fibres. No immunostaining for vitronectin was observed in cross-sections through the nerve outgrowth. Our results suggest that the environment formed during nerve regrowth within a knitted prosthesis provides conditions supporting the regeneration of nerve fibres. The extracellular matrix formed in a knitted prosthesis, which was applied between the stumps of a transected sciatic nerve of the rat, was investigated to find out whether it provided suitable conditions for nerve regeneration. After 6 weeks, the prosthesis contained a nerve outgrowth connecting the nerve stumps. The immunohistochemical staining of the cryostat sections through the middle of the nerve prosthesis revealed that thrombospondin, fibronectin, chondroitin sulfate A and C, and type IV collagen were localised in the connective tissue surrounding the nerve outgrowth, in the perineurium of individual minifascicles, as well as in the endoneurium among regenerated nerve fibres. No immunostaining for vitronectin was observed in cross-sections through the nerve outgrowth. Our results suggest that the environment formed during nerve regrowth within a knitted prosthesis provides conditions supporting the regeneration of nerve fibres. (en) Extracelulární matrix je tvořena podél regenerujících axonů v pletené nervové protéze. (cs)
Title	Imunohistochemická studie ECM během regenerace periferního nervu přes pletenou protézu (cs) Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis (en)
skos:prefLabel	Imunohistochemická studie ECM během regenerace periferního nervu přes pletenou protézu (cs) Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis Immunohistochemical study of the extracellular matrix formed during peripheral nerve regeneration through a knitted prosthesis (en)
skos:notation	RIV/00216224:14110/01:00005656!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA309/00/0407)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Hradilová Svíženská, Ivana Dubový, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	682413
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00005656
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Regeneration; Peripheral nerve; Extracellular matrix; Immunohistochemistry (en)
http://linked.open.../riv/klicoveSlovo	Extracellular matrix Immunohistochemistry Regeneration Peripheral nerve
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0FDC93251E7C]
http://linked.open...i/riv/nazevZdroje	Scripta medica
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and extracellular environment for the axon regeneration following injury of the spinal roots and peripheral nerves
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Dubový, Petr Hradilová Svíženská, Ivana
issn	1211-3395
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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