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| Description
| - Centre for cardiovascular research-Study of molecular and cellular mechanisms involved in the origin and progression of ischemic heart disease (IHD), with particular attention to its most important risk factors, e.g. atherosclerosis and hypertension.Research will concetrate upon following closely related areas: (i) mechanisms of cardiac tolerance to oxygen deprivation and the role of risk factors; (ii) stabilization of the vulnerable plaque and genetic determinants of atherogenesis; (iii) molecularmechanisms of the reactivity of peripheral vessels in hypertension; (iv) late effects of early disturbances of the cardiovascular system. Ontogenetic and gender aspects will belong to the main research strategy of the proposed centre. Clinical researchis expected to be its integral part. Understanding of pathogenetic mechanisms of IHD should lead to the development of novel preventive, diagnostic and therapeutic approaches. This project is in agreement with the priorities of EU for the next ten years. (en)
- Centrum výzkumu chorob srdce a cév. Studium molekulárních a buněčných mechanizmů, které se podílejí na vzniku a rozvoji ischemické choroby srdeční (ICHS) se zvláštním zřetelem k jejím nejzávažnějším rizikovým faktorům, tj. ateroskleróze a hypertenzi.Výzkum se bude týkat těchto vzájemně souvisejících oblastí: (i) mechanizmů odolnosti srdce k nedostatku kyslíku a úlohy rizikových faktorů; (ii) možnosti stabilizace vulnerabilního plátu a genetických příčin aterogeneze; (iii) molekulárních mechanizmůreaktivity periferních cév při hypertenzi; (iv) pozdních důsledků časného poškození kardiovaskulárního systému. K hlavním strategickým přístupům budou patřit vývojové aspekty a sexuální odlišnosti. Integrální součástí bude klinický výzkum. Pochopenípatogenetických mechanizmů, které se podílejí na vzniku ICHS, by mělo vést k novým preventivním, diagnostickým a terapeutickým postupům. Navrhovaný projekt je v plném souladu s prioritami kardiovaskulárního výzkumu ve státech EU na příštích 10 let.
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| Title
| - Centre for cardiovascular research (en)
- Centrum výzkumu chorob srdce a cév
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - ischemic heart disease, atherosclerosis, systemic hypertension, pulmonary hypertension, ontogenetic aspects, gender differences. (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Projekt přinesl řadu nových poznatků v oblasti studia molekulárních a buněčných mechanizmů, které se podílejí na vzniku a rozvoji ischemické choroby srdeční a výzkumu jejích hlavních rizikových faktorů. Kladem projektu je syntéza kvalitního základního a klinického výzkumu a orientace na možnosti klinického využití. Projekt přinesl kvalitní výsledky a cíle programu byly splněny. (cs)
- The project generated new knowledge on molecular and cellular mechanisms involved in the ischemic heart disease and research of its major risk factors. Synthesis of good quality basic and clinical research was one of the important attributes of this project clearly oriented to clinical applications. The aims of the project were achieved. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - ischemic heart disease
- atherosclerosis
- ontogenetic aspects
- pulmonary hypertension
- systemic hypertension
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| is http://linked.open...vavai/riv/projekt
of | - Program PMR - monitorování a záznam tlaku krve v srdci
- Zařízení pro snímání elektrické aktivity srdce malých hlodavců
- Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
- Transpulmonary B-Type Natriuretic Peptide Uptake and Cyclic Guanosine Monophosphate Release in Heart Failure and Pulmonary Hypertension The Effects of Sildenafil
- Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in apoE-deficient mice fed standard low cholesterol diet
- Separation of tryptic peptides of native and glycated BSA using open-tubular CEC with salophene-lanthanide-Zn2+ complex as stationary phase
- The pi-helix formation between Asp(369) and Thr(375) as a key factor in E(1)-E(2) conformational change of Na(+)/K(+)-ATPase
- Atropine may prevent the development of neurogenic pulmonary edema
- The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions
- MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe.
- The FTO gene and obesity in a large Eastern European population sample: The HAPIEE study
- APOA5 Ala315>Val, identified in patients with severe hypertriglyceridemia, is a common mutation with no major effects on plasma lipid levels.
- No significant association between A-501C single nucleotide polymorphism in preproghrelin and body mass index or waist-to-hip ratio in central European population.
- Apolipoprotein A-V variant (T-1131>C) affects plasma levels of non-high-density lipoprotein cholesterol in Caucasians
- Vliv reprodukčního stárnutí na kardiovaskulární změny u žen
- Apolipoprotein E Arg136 --> Cys mutation and hyperlipidemia in a large central European population sample
- Sex-specific interaction between APOE and APOA5 variants and determination of plasma lipid levels
- Catheter-based management of aortic valve regurgitation in experimental cardiology
- Common Genetic Variants in ANK2 Modulate QT Interval: Results From the KORA Study
- Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats
- Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension
- Eat less and exercise more - is it really enough to knock down the obesity pandemia?
- Life style change and reverse cholesterol transport in obese women
- Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension
- Vvoj odolnosti srdenho svalu k nedostatku kyslku - experimentln aspekty
- Genetick predispozice a riziko nhl srden smrti v dsledku malignch arytmi
- Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls
- Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction
- Impact of apolipoprotein A5 variants on statin treatment efficacy
- A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies
- Molekulární genetika dyslipidemií
- Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: Does heterogeneity of estimates relate to study design?
- Renal interactions of renin-angiotensin system, nitric oxide and superoxide anion: implications in the pathophysiology of halt-hensitivity and hypertension
- Cholesterol induces renal vasoconstriction and anti-natriuresis by inhibiting nitric oxide production in anesthetized rats
- Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats
- Vascular endothelial cells on two-and three-dimensional fibrin assemblies for biomaterial coatings
- Single-stage Extensive Chronic type a dissecting aortic aneurysm repair and continuous-flow ventricular assist device implantation
- Tissue reaction to three different types of tissue glues in an experimental aorta dissection model - a quantitative approach
- Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats
- Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats
- Antiatherogenic effect of simvastatin is not due to decrease of LDL cholesterol in ovariectomized golden syrian hamster
- INSIG2 promoter variant, obesity markers and lipid parameters - no association in a large Slavonic Caucasian population sample
- Why we are not able to find the cheart disease gene - apoE as an example
- N-acetylcysteine attenuates lodine contrast agent-induced nephropathy in 5/6-nephrectomized rats
- High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity
- Lack of association between a new tag SNP in the FTO gene and BMI in Czech-Slavonic population
- APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample.
- Knockout of angiotensin 1-7 receptor mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II
- Katetrizační ablace komorových tachykardií: přehled literatury a vlastních zkušeností
- Epikardiální ablace komorových tachykardií
- Aorta transplantation in young apolipoprotein E-deficient mice: Possible model for studies on regression of atherosclerotic lesions?
- Comprehensive management of severe intestinal bleeding in a patient supported for 94 days by the biventricular Levitronix CentriMag system
- Catheter ablation of arrhythmic storm triggered by monomorphic ectopic beats in patients with coronary artery disease
- Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population
- FTO variant, energy Intake, physical activity and basal metabolic rate in caucasians. The HAPIEE study
- Glycerol-3-phosphate Dehydrogenase Expression and Oxygen Consumption in Liver Mitochondria of Female and Male Rats with Chronic Alteration of Thyroid Status
- Generation of hydrogen peroxide in the developing rat heart: the role of elastin metabolism
- Gene-Environment Interactions: Their Role in Hypertension Development
- Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats
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