About: High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A deficiency in nitric oxide (NO) generation leads to salt-sensitive hypertension, but the role of increased superoxide (O(2)(-)) in such salt sensitivity has not been delineated. We examined the hypothesis that an enhancement in O(2)(-) activity induced by high-salt (HS) intake under deficient NO production contributes to the development of salt-sensitive hypertension. Endothelial NO synthase knockout (eNOS KO; total n = 64) and wild-type (WT; total n = 58) mice were given diets containing either normal (NS; 0.4%) or high-salt (HS; 4%) for 2 wk. During this period, mice were chronically treated with a O(2)(-) scavenger, tempol (400 mg/l), or an inhibitor of NADPH oxidase, apocynin (1 g/l), in drinking water or left untreated (n = 6-8 per group). Blood pressure was measured by radiotelemetry and 24-h urine samples were collected in metabolic cages. Basal mean arterial pressure (MAP) in eNOS KO was higher (125 +/- 4 vs. 106 +/- 3 mmHg) compared with WT. Feeding HS diet did not alter MAP in WT but incre A deficiency in nitric oxide (NO) generation leads to salt-sensitive hypertension, but the role of increased superoxide (O(2)(-)) in such salt sensitivity has not been delineated. We examined the hypothesis that an enhancement in O(2)(-) activity induced by high-salt (HS) intake under deficient NO production contributes to the development of salt-sensitive hypertension. Endothelial NO synthase knockout (eNOS KO; total n = 64) and wild-type (WT; total n = 58) mice were given diets containing either normal (NS; 0.4%) or high-salt (HS; 4%) for 2 wk. During this period, mice were chronically treated with a O(2)(-) scavenger, tempol (400 mg/l), or an inhibitor of NADPH oxidase, apocynin (1 g/l), in drinking water or left untreated (n = 6-8 per group). Blood pressure was measured by radiotelemetry and 24-h urine samples were collected in metabolic cages. Basal mean arterial pressure (MAP) in eNOS KO was higher (125 +/- 4 vs. 106 +/- 3 mmHg) compared with WT. Feeding HS diet did not alter MAP in WT but incre (en)
Title	High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity (en)
skos:prefLabel	High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity (en)
skos:notation	RIV/00023001:_____/10:00002318!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GP305/08/P053), P(KJB502030801), P(NS9699), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	299
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Husková, Zuzana Červenka, Luděk Kopkan, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	261602
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002318
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	superoxide anion; nitric oxide; kidney function; hypertension (en)
http://linked.open.../riv/klicoveSlovo	hypertension - ischaemic heart disease - cardiac failure - vitamin D kidney function nitric oxide superoxide anion
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5B9F5CC21D6A]
http://linked.open...i/riv/nazevZdroje	American Journal of Physiology-Renal Physiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension Centre for cardiovascular research Contribution of the RAAS to the pathophysiology of salt-sensitive hypertension: a study in renin transgenic rats with inducible hypertension The role of interaction between nitric oxide, oxidative stress and renin-angiotensin system in the regulation of renal function and blood pressure in mice lacking gene for endothelial nitric oxide synthase with renovascular hypertension
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Husková, Zuzana Červenka, Luděk Kopkan, Libor Hess, A. Majid, DSA Navar, L. G.
http://linked.open...ain/vavai/riv/wos	000281537700019
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	1931-857X
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity

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