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| rdf:type
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| Description
| - Aims: The present study was performed to evaluate the effects of target disruption of the G-protein-coupled receptor Mas for angiotensin 1-7 [Ang(1-7)] in knockout mice on the course of two-kidney, one-clip (2K1C) Goldblatt hypertension. Methods: Knockout and wild-type mice underwent clipping of one renal artery. Blood pressure (BP) was monitored by radiotelemetry. The mice were either untreated or chronically treated with the superoxide (O-2(-)) scavenger tempol (400 mg/l) or the inhibitor of NADPH oxidase apocynin (1 g/l) administered in drinking water. Results: Knockout mice responded to clipping by accelerated increases in BP and the final BP was significantly higher than that in wildtype mice. Chronic treatment with tempol or apocynin elicited similar antihypertensive effects in 2K1C/knockout as in 2K1C/wild-type mice. Acute nitric oxide synthase inhibition caused greater BP increases in 2K1C/wild-type than in 2K1C/knockout mice. Conclusion: Our present findings support the notion that the angiot
- Aims: The present study was performed to evaluate the effects of target disruption of the G-protein-coupled receptor Mas for angiotensin 1-7 [Ang(1-7)] in knockout mice on the course of two-kidney, one-clip (2K1C) Goldblatt hypertension. Methods: Knockout and wild-type mice underwent clipping of one renal artery. Blood pressure (BP) was monitored by radiotelemetry. The mice were either untreated or chronically treated with the superoxide (O-2(-)) scavenger tempol (400 mg/l) or the inhibitor of NADPH oxidase apocynin (1 g/l) administered in drinking water. Results: Knockout mice responded to clipping by accelerated increases in BP and the final BP was significantly higher than that in wildtype mice. Chronic treatment with tempol or apocynin elicited similar antihypertensive effects in 2K1C/knockout as in 2K1C/wild-type mice. Acute nitric oxide synthase inhibition caused greater BP increases in 2K1C/wild-type than in 2K1C/knockout mice. Conclusion: Our present findings support the notion that the angiot (en)
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| Title
| - Knockout of angiotensin 1-7 receptor mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II
- Knockout of angiotensin 1-7 receptor mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II (en)
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| skos:prefLabel
| - Knockout of angiotensin 1-7 receptor mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II
- Knockout of angiotensin 1-7 receptor mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II (en)
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| skos:notation
| - RIV/00023001:_____/10:00002386!RIV11-MZ0-00023001
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - N, P(1M0510), P(GA305/07/0167), P(GC305/07/J004), P(GC305/08/J006), P(GP305/08/P053), P(IAA511700701), P(NS10499), P(NS9703), Z(MZ0IKEM2005)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
| - Malý, Jan
- Bürgelová, Marcela
- Vaňourková, Zdeňka
- Husková, Zuzana
- Červenka, Luděk
- Netuka, Ivan
- Vaněčková, Ivana
- Opočenský, Martin
- Mrázová, Iveta
- Rakušan, Dan
- Škaroupková, Petra
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/10:00002386
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - two-kidney, one-clip Goldblatt hypertension; mas receptor knockout mice; nitric oxide deficiency (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Kidney and Blood Pressure Research
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bürgelová, Marcela
- Husková, Zuzana
- Malý, Jan
- Mrázová, Iveta
- Netuka, Ivan
- Vaněčková, Ivana
- Vaňourková, Zdeňka
- Červenka, Luděk
- Kramer, H. J.
- Škaroupková, Petra
- Bader, M.
- Opočenský, Martin
- Rakušan, Dan
- Alenina, N.
- Santos, R. A.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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