About: A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

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About: A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea (en)
Title	A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies (en)
skos:prefLabel	A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies (en)
skos:notation	RIV/00023001:_____/09:00001970!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(1M0510), V, Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Piťha, Jan Hubáček, Jaroslav Lánská, Věra Poledne, Rudolf Adámková, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	301168
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00001970
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FTO; BMI; polymorphism; menopausal status (en)
http://linked.open.../riv/klicoveSlovo	BMI FTO polymorphism menopausal status
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[94725BEE09B4]
http://linked.open...i/riv/nazevZdroje	Clinical chemistry and laboratory medicine
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Adámková, Věra Hubáček, Jaroslav Lánská, Věra Poledne, Rudolf Piťha, Jan
http://linked.open...ain/vavai/riv/wos	000266014200002
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	1434-6621
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies

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