About: Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated. Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated. (en)
Title	Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction (en)
skos:prefLabel	Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction (en)
skos:notation	RIV/00023001:_____/09:00001968!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0510), P(NR9093)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Piťha, Jan Hubáček, Jaroslav Poledne, Rudolf Staněk, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	303710
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00001968
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apolipoprotein E; acute coronary syndrome; polymorphism (en)
http://linked.open.../riv/klicoveSlovo	apolipoprotein E polymorphism acute coronary syndrome
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[86E5CF2FE181]
http://linked.open...i/riv/nazevZdroje	Folia biologica (Praha)
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetical determination of acute coronary syndromes - population study Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Hubáček, Jaroslav Poledne, Rudolf Piťha, Jan Staněk, Vladimír Skalická, H. Aschermann, M.
http://linked.open...ain/vavai/riv/wos	000267604600006
issn	0015-5500
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction

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