About: Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The possible association between the end-stage renal disease (ESRD) and apolipoprotein E (APOE) polymorphism was found in some, but not all studies. We have analysed the APOE genotypes in 995 haemodialysed patients (cases) and a sample of 6242 healthy individuals (controls) in the Czech Republic. There was a statistically significant difference in the frequencies of APOE alleles between the cases and controls, with more carriers of the APOE2 allele in ESRD patients (15.9%) than in controls (12.2%) (p=0.005). The odds ratio of ESRD for the APOE2 allele, compared with APOE3E3 homozygotes, was 1.37 (95% confidence interval 1.13-1.67). The strength of the association increased with the time spent on haemodialysis: the odds ratios of all-cause ESRD in patients dialysed for 8 or more years, 1-8 years and less than one year (non-survivors) were 1.27 (0.94-1.71), 1.41 (1.09-1.81) and 1.94 (0.88-4.18), respectively. This study suggests that the APOE2 allele is a possible genetic risk factor for all-cause ESRD The possible association between the end-stage renal disease (ESRD) and apolipoprotein E (APOE) polymorphism was found in some, but not all studies. We have analysed the APOE genotypes in 995 haemodialysed patients (cases) and a sample of 6242 healthy individuals (controls) in the Czech Republic. There was a statistically significant difference in the frequencies of APOE alleles between the cases and controls, with more carriers of the APOE2 allele in ESRD patients (15.9%) than in controls (12.2%) (p=0.005). The odds ratio of ESRD for the APOE2 allele, compared with APOE3E3 homozygotes, was 1.37 (95% confidence interval 1.13-1.67). The strength of the association increased with the time spent on haemodialysis: the odds ratios of all-cause ESRD in patients dialysed for 8 or more years, 1-8 years and less than one year (non-survivors) were 1.27 (0.94-1.71), 1.41 (1.09-1.81) and 1.94 (0.88-4.18), respectively. This study suggests that the APOE2 allele is a possible genetic risk factor for all-cause ESRD (en)
Title	Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls (en)
skos:prefLabel	Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls (en)
skos:notation	RIV/00023001:_____/09:00001967!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0510), P(NR7958)
http://linked.open...iv/cisloPeriodika	9-10
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Viklický, Ondřej Hubáček, Jaroslav Bloudíčková, Silvie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	303711
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00001967
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apolipoprotein E; renal failure; polymorphism (en)
http://linked.open.../riv/klicoveSlovo	apolipoprotein E polymorphism renal failure
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6F2CD560D412]
http://linked.open...i/riv/nazevZdroje	Biochemical Genetics
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research Genetic basis of syndrome MIA (Malnutrition - Inflammation - Atherosclerosis) - complication of hemodialysis treatment
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Hubáček, Jaroslav Viklický, Ondřej Bobák, M. Pikhart, H. Bloudíčková, Silvie Kubinová, R.
http://linked.open...ain/vavai/riv/wos	000269911300009
issn	0006-2928
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls Apolipoprotein E polymorphism in hemodialyzed patients and healthy controls

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