About: Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats     Goto   Sponge   NotDistinct   Permalink

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  • The aim of this study was to evaluate the role of the ET system in male heterozygous TGR with established hypertension (late-onset treatment). TGR and control Hannover Sprague´Dawley (HanSD) rats were fed a high-salt diet and were treated concomitantly with the nonselective ETA/B receptor blocker bosentan or the selective ETA receptor blocker atrasentan from day 52 of age on. Survival rate was partly increased by bosentan and fully normalized with atrasentan. Atrasentan significantly reduced BP as early as one week after the start of the treatment. Bosentan improved and atrasentan almost restored podocyte architecture and reversed changes in podocyte phenotype. Our results demonstrate that selective ETA receptor blockade has more favorable effects than nonselective ETA/B receptor blockade and ETA receptor blockade has similar effects in heterozygous rats with established hypertension as in young animals with developing hypertension.
  • The aim of this study was to evaluate the role of the ET system in male heterozygous TGR with established hypertension (late-onset treatment). TGR and control Hannover Sprague´Dawley (HanSD) rats were fed a high-salt diet and were treated concomitantly with the nonselective ETA/B receptor blocker bosentan or the selective ETA receptor blocker atrasentan from day 52 of age on. Survival rate was partly increased by bosentan and fully normalized with atrasentan. Atrasentan significantly reduced BP as early as one week after the start of the treatment. Bosentan improved and atrasentan almost restored podocyte architecture and reversed changes in podocyte phenotype. Our results demonstrate that selective ETA receptor blockade has more favorable effects than nonselective ETA/B receptor blockade and ETA receptor blockade has similar effects in heterozygous rats with established hypertension as in young animals with developing hypertension. (en)
  • Cílem studie bylo zjistit roli endotelinového systému u samčích heterozygotů TGR s již rozvinutou hypertenzí. TGR a kontrolní Hannover Sprague-Dawley potkanům na vysokoslané dietě byly od 52 dne života podávány neselektivní blokátor ETA/B receptorů bosentan a selektivní blokátor ETA receptorů atrasentan. Atrasentan výrazně snížil TK již týden po zahájení léčby. Bosentan zlepšil a atrasentan prakticky kompletně reparoval architekturální a fenotypové změny podocytů. Naše výsledky ukazují, že selektivní blokáda ETA receptorů má výrazně lepší efekt než neselektivní blokáda ETA/B receptorů a že selektivní blokáda ETA receptorů má podobný efekt u heterozygotních TGR s vyvinutou hypertenzí jako u mladých zvířat s rozvíjející se hypertenzí. (cs)
Title
  • Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
  • Pozdní začátek blokády endotelinových receptorů u heterozygotních hypertenzních REN-2 potkanů (cs)
  • Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats (en)
skos:prefLabel
  • Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
  • Pozdní začátek blokády endotelinových receptorů u heterozygotních hypertenzních REN-2 potkanů (cs)
  • Late-onse endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats (en)
skos:notation
  • RIV/00216208:11120/08:00000565!RIV09-GA0-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0510), P(GC305/07/J004), V, Z(MZ000023001), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika
  • 4-6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 376328
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/08:00000565
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ETA and ETB receptors; Heterozygous transgenic Ren-2 rats; Hypertension; End-organ damage; Podocytes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D12121622A47]
http://linked.open...i/riv/nazevZdroje
  • Vascular Pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 48
http://linked.open...iv/tvurceVysledku
  • Vernerová, Zdeňka
  • Eis, Václav
http://linked.open...ain/vavai/riv/wos
  • 000256778300004
http://linked.open...n/vavai/riv/zamer
issn
  • 1537-1891
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
is http://linked.open...avai/riv/vysledek of
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