About: Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension

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About: Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Selective blockade of ETA receptors is superior to nonselective ETA/ETB in attenuating hypertension, ET-1 concentrations, and survival rate in Ren-2 rats. In the present study, we were interested whether similar effects will be found in transgenic rats with inducible malignant hypertension, which were derived from this original Ren-2 strain. Our data show that blockade of the ET system in IHR does not prevent or attenuate the development of severe hypertension induced by I3C feeding in IHR. Selective blockade of ETA receptors is superior to nonselective ETA/ETB in attenuating hypertension, ET-1 concentrations, and survival rate in Ren-2 rats. In the present study, we were interested whether similar effects will be found in transgenic rats with inducible malignant hypertension, which were derived from this original Ren-2 strain. Our data show that blockade of the ET system in IHR does not prevent or attenuate the development of severe hypertension induced by I3C feeding in IHR. (en)
Title	Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension (en)
skos:prefLabel	Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension (en)
skos:notation	RIV/00023001:_____/09:00001947!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GC305/07/J004), P(NS9703), Z(MZ000023001), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	5-6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dvořák, Pavel Malý, Jan Vaňourková, Zdeňka Husková, Zuzana Červenka, Luděk Vaněčková, Ivana Chábová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	313176
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00001947
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypertension; inducible; endothelin receptors; Cyp1A1-Ren-2 rats (en)
http://linked.open.../riv/klicoveSlovo	hypertension - ischaemic heart disease - cardiac failure - vitamin D Cyp1A1-Ren-2 rats endothelin receptors inducible
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F3FDB59A16F9]
http://linked.open...i/riv/nazevZdroje	Vascular pharmacology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel approach to blood pressure control and organ protection- intervention to renin-angiotensin and endothelin systems The roles of renin-angiotensin and endothelin systems in the pathophysiology of ANG II-dependent hypertension Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Dvořák, Pavel Husková, Zuzana Malý, Jan Tesař, Vladimír Vaněčková, Ivana Vaňourková, Zdeňka Červenka, Luděk Kramer, Herbert J. Čertíková-Chábová, Věra Erbanová, Michaela Bäcker, Angela
http://linked.open...ain/vavai/riv/wos	000264329700008
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů Nové aspekty patofyziologie, prevence, diagnostiky a léčby nejzávažnějších onemocnění v české populaci
issn	1537-1891
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension

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