About: Topoisomerase I

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Topoisomerase I
equivalentClass	nodeID://b640696
OMIM_Number	126420
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Topoisomerase I
UMLS_CUI	C0012920
Legacy_Concept_Name	Topoisomerase-I
FULL_SYN	Type I DNA TopoisomeraseSYNCI Topoisomerase 1SYNCI Topoisomerase IPTNCI TOP1SYNCI Topo ISYNCI DNA Topoisomerase ISYNCI Topoisomerase (DNA) ISYNCI Topoisomerase, DNA, ISYNCI EC 5.99.1.2SYNCI
Swiss_Prot	P11387
DEFINITION	DNA topoisomerase I (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology.NCI
DesignNote	DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus).
code	C16516
sameAs	DNA Topoisomerases, Type I
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0381011
is someValuesFrom of	nodeID://b645387 nodeID://b649737 nodeID://b676908 nodeID://b684357 nodeID://b684373 nodeID://b686993 nodeID://b698188 nodeID://b703702 nodeID://b708058 nodeID://b719919 nodeID://b720081 nodeID://b725479
is Has_Target of	IRINOTECAN Pegylated Liposomal Irinotecan Silatecan AR-67 Tenifatecan IRINOTECAN HYDROCHLORIDE Pyrazoloacridine Becatecarin Gimatecan Belotecan Hydrochloride Polyethyleneglycol-7-ethyl-10-hydroxycamptothecin
is sameAs of	DNA Topoisomerases, Type I

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