About: Gimatecan

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Gimatecan
rdfs:subClassOf	Camptothecin Analogue nodeID://b676906 nodeID://b676907 nodeID://b676908 nodeID://b676909 nodeID://b676910
Has_Target	DNA Topoisomerases, Type I
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Gimatecan
UMLS_CUI	C0969276
CAS_Registry	292618-32-7
In_Clinical_Trial_For	Advanced Solid Tumor; Malignant Glioma
FDA_UNII_Code	7KKS9R192F
Contributing_Source	FDA
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID	537638
PDQ_Closed_Trial_Search_ID	537638
Chemical_Formula	C25H25N3O5
Legacy_Concept_Name	Gimatecan
FULL_SYN	7-t-ButoxyiminomethylcamptothecinSNNCI ST1481PTNCI-GLOSSCDR0000386216 LBQ707CNNCI STI481CNNCI GIMATECANPTFDA7KKS9R192F GimatecanPTNCI gimatecanPTNCI-GLOSSCDR0000386214
DEFINITION	An orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF).NCI
code	C65804
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0397314

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