About: Irinotecan

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Irinotecan
rdfs:subClassOf	Camptothecin Analogue nodeID://b684365 nodeID://b684366 nodeID://b684367 nodeID://b684368 nodeID://b684369 nodeID://b684370 nodeID://b684371 nodeID://b684372 nodeID://b684373
Has_Salt_Form	IRINOTECAN HYDROCHLORIDE
Has_Target	DNA Topoisomerases, Type I
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Irinotecan
NSC_Code	616348 728073
UMLS_CUI	C0123931
CAS_Registry	97682-44-5
FDA_UNII_Code	7673326042
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog.NCI-GLOSS
Chemical_Formula	C33H38N4O6
Legacy_Concept_Name	Irinotecan_Base
FULL_SYN	irinotecanPTNCI-GLOSSCDR0000045391 (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylateSNNCI 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecinSNNCI [1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl esterSNNCI (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dioneSNNCI IRINOTECANPTFDA7673326042 IrinotecanSYDTPNSC0616348 IrinotecanPTNCI
DEFINITION	A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.NCI
code	C62040
sameAs	IRINOTECAN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0147530
is Has_Free_Acid_Or_Base_Form of	IRINOTECAN HYDROCHLORIDE
is sameAs of	IRINOTECAN IRINOTECAN

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