About: Irinotecan Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Irinotecan Hydrochloride
rdfs:subClassOf	Camptothecin Analogue nodeID://b684350 nodeID://b684351 nodeID://b684352 nodeID://b684353 nodeID://b684354 nodeID://b684355 nodeID://b684356 nodeID://b684357 nodeID://b684358
Has_Free_Acid_Or_Base_Form	IRINOTECAN
Has_Target	DNA Topoisomerases, Type I
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Irinotecan Hydrochloride
UMLS_CUI	C0594375
CAS_Registry	136572-09-3
Accepted_Therapeutic_Use_For	State IVB Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric cancer; Non-small cell lung cancer; Small cell lung cancer
In_Clinical_Trial_For	Hepatocellular carcinoma; neuroblastoma; non-small cell lung cancer; pancreatic cancer; penile cancer; rhabdomyosarcoma; small bowel adenocarcinoma; small cell lung cancer; transitional cell cancer; unspecified solid tumors Breast cancer; brain metastases; colorectal cancer; esophageal cancer; Ewings sarcoma; gastric or gastroesophageal adenocarcinoma; glioblastoma multiforme; gliomas
FDA_UNII_Code	042LAQ1IIS
Contributing_Source	FDA
ALT_DEFINITION	A drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Camptosar blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41714
PDQ_Closed_Trial_Search_ID	41714
Chemical_Formula	C33H38N4O6.HCl.3H2O
Legacy_Concept_Name	Irinotecan
FULL_SYN	irinotecan hydrochloridePTNCI-GLOSSCDR0000635811 CPT 11SYDTPNSC0616348 Irinotecan HydrochloridePTNCI CPT 11PTNCI-GLOSSCDR0000044427 Camptothecin-11SYNCI Camptothecin 11SYDTPNSC0616348 IRINOTECAN HYDROCHLORIDEPTFDA042LAQ1IIS CPT-11CNNCI CamptoFBNCI CamptosarSYDTPNSC0616348 U-101440ECNNCI CamptosarBRNCI CamptosarPTNCI-GLOSSCDR0000635812
DEFINITION	The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.NCI
code	C1381
sameAs	IRINOTECAN HYDROCHLORIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0398524
is someValuesFrom of	nodeID://b642629 nodeID://b642631 nodeID://b645326 nodeID://b645360 nodeID://b650309 nodeID://b650338 nodeID://b650352 nodeID://b651485 nodeID://b656618 nodeID://b656640 nodeID://b656644 nodeID://b657222 nodeID://b657224 nodeID://b657226 nodeID://b657711 nodeID://b658236 nodeID://b658246 nodeID://b658692 nodeID://b658700 nodeID://b658707 nodeID://b660179 nodeID://b660263 nodeID://b660304 nodeID://b660307 nodeID://b660423 nodeID://b660446 nodeID://b660448 nodeID://b660452 nodeID://b660456 nodeID://b662511 nodeID://b663742 nodeID://b663744 nodeID://b664302 nodeID://b666516 nodeID://b667172 nodeID://b668249 nodeID://b670547 nodeID://b670742 nodeID://b672449 nodeID://b672457 nodeID://b672461 nodeID://b673663 nodeID://b673677 nodeID://b673712 nodeID://b673824 nodeID://b673930 nodeID://b673933 nodeID://b673935 nodeID://b673942 nodeID://b673945 nodeID://b674162 nodeID://b676654 nodeID://b676686

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