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AttributesValues
rdf:type
rdfs:label
  • Becatecarin
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Becatecarin
NSC_Code
  • 655649
UMLS_CUI
  • C0936065
CAS_Registry
  • 119673-08-4
In_Clinical_Trial_For
  • Hepatobiliary carcinoma; leukemia; myelodysplastic syndromes; neuroblastoma; small cell lung cancer; unspecified solid tumors
FDA_UNII_Code
  • A60X6MBU6G
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42257
PDQ_Closed_Trial_Search_ID
  • 42257
Chemical_Formula
  • C33H34Cl2N4O7
Legacy_Concept_Name
  • Rebeccamycin_Analogue
FULL_SYN
  • BMY-27557-14CNNCI
  • BecatecarinPTNCI
  • Rebeccamycin analogSYDTPNSC0655649
  • rebeccamycin analogPTNCI-GLOSSCDR0000393543
  • Rebeccamycin Analogue, Tartrate SaltSYNCI
  • 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-SNNCI
  • XL119CNNCI
  • DEAE-RebeccamycinSYNCI
  • BECATECARINPTFDAA60X6MBU6G
  • NSC 655649PTNCI-GLOSSCDR0000405883
  • BMS-181176CNNCI
  • Rebeccamycin AnalogueSYNCI
  • 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dionePTDCP50520
DEFINITION
  • A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)NCI
code
  • C1620
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