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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tenifatecan
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tenifatecan
UMLS_CUI
  • C1883354
CAS_Registry
  • 850728-18-6
FDA_UNII_Code
  • 7G0Y719Q80
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 518315
PDQ_Closed_Trial_Search_ID
  • 518315
Chemical_Formula
  • C55H72N2O9
Legacy_Concept_Name
  • Tocopherol_Succinate_7-Ethyl-10-Hydroxycamptothecin
FULL_SYN
  • TenifatecanPTNCI
  • SN2310CNNCI
  • (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin- 9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl ButanedioateSNNCI
  • SN-2310CNNCI
  • TENIFATECANPTFDA7G0Y719Q80
  • Tocopherol Succinate 7-Ethyl-10-HydroxycamptothecinSNNCI
DEFINITION
  • A highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and triggers programmed cell death. SN2310 emulsion provides longer circulation time and potentiates drug exposure as compared to the unconjugated SN-38.NCI
code
  • C64772
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