About: Belotecan Hydrochloride

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Belotecan Hydrochloride
rdfs:subClassOf	Camptothecin Analogue nodeID://b649735 nodeID://b649736 nodeID://b649737 nodeID://b649738 nodeID://b649739
Has_Free_Acid_Or_Base_Form	Belotecan
Has_Target	DNA Topoisomerases, Type I
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Belotecan Hydrochloride
UMLS_CUI	C0762739
CAS_Registry	213819-48-8
FDA_UNII_Code	01DZ4127G7
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	537355
PDQ_Closed_Trial_Search_ID	537355
Chemical_Formula	C25H27N3O4.ClH
Legacy_Concept_Name	Belotecan_Hydrochloride
FULL_SYN	Belotecan HydrochloridePTNCI BELOTECAN HYDROCHLORIDEPTFDA01DZ4127G7 CKD602 HClCNNCI belotecan hydrochloridePTNCI-GLOSSCDR0000630919
DEFINITION	The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.NCI
code	C66954
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0300454
is Has_Salt_Form of	Belotecan

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