About: Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study examined whether metformin would improve cardiac function and survival also in non-diabetic heart failure of male Wistar rats. Metformin therapy normalized serum NEFAs, decreased myocardial glucose oxidation, increased myocardial palmitate oxidation, but it had no effect on myocardial gene expression, AMPK (AMP-activated protein kinase) signalling, ATP level, mitochondrial respiration, cardiac morphology, function and long-term survival, despite reaching therapeutic serum levels in rats with creating aortocaval fistula. In conclusion, metformin-induced enhancement of myocardial fatty acid oxidation had a neutral effect on cardiac function and survival. Reported cardioprotective effects of metformin may not be universal to all forms of heart failure and may require AMPK activation or ATP depletion. No increase in mortality on metformin supports its safe use in diabetic heart failure The present study examined whether metformin would improve cardiac function and survival also in non-diabetic heart failure of male Wistar rats. Metformin therapy normalized serum NEFAs, decreased myocardial glucose oxidation, increased myocardial palmitate oxidation, but it had no effect on myocardial gene expression, AMPK (AMP-activated protein kinase) signalling, ATP level, mitochondrial respiration, cardiac morphology, function and long-term survival, despite reaching therapeutic serum levels in rats with creating aortocaval fistula. In conclusion, metformin-induced enhancement of myocardial fatty acid oxidation had a neutral effect on cardiac function and survival. Reported cardioprotective effects of metformin may not be universal to all forms of heart failure and may require AMPK activation or ATP depletion. No increase in mortality on metformin supports its safe use in diabetic heart failure (en)
Title	Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats (en)
skos:prefLabel	Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats (en)
skos:notation	RIV/68378050:_____/11:00366961!RIV12-MZ0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(1M0520), P(GA305/09/1390), P(LC06044), P(NS10300), P(NS10497), P(NS9757), Z(AV0Z50110509), Z(AV0Z50200510), Z(AV0Z50520514), Z(MSM0021620806), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Strnad, Hynek Kolář, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	196351
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00366961
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	AMP-activated protein kinase; energy metabolism; heart failure; metformin; survival; volume overload (en)
http://linked.open.../riv/klicoveSlovo	heart failure metformin survival AMP-activated protein kinase energy metabolism volume overload
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2A8F8271BC71]
http://linked.open...i/riv/nazevZdroje	Clinical Science and Clinical Science and Molecular Medicine
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Centre for cardiovascular research Center for Experimental Hematology Therapeutic and diagnostic potential of hepcidin. The role of C reactive protein in the pathogenesis of metabolic syndrome: nutritional and pharmacological interventions Investigation of metabolic mechanisms of heart failure progression in an experimental model Metabolic factors involved in progression of chronic heart failure
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	121
http://linked.open...iv/tvurceVysledku	Benada, Oldřich Kolář, Michal Kazdová, L. Kopecký, Jan Strnad, Hynek Beneš, J. Drahota, Zdeněk Houštěk, Josef Kovářová, Nikola Medříková, Daša Melenovsky, V. Petrák, J. Sedmera, David Vrbacký, Marek Červenka, L. Škaroupková, P.
http://linked.open...ain/vavai/riv/wos	000293155200004
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Microorganisms in Research and Biotechnology Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0143-5221
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1042/CS20100527
is http://linked.open...avai/riv/vysledek of	Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software