About: Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů

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About: Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Zamer, within Data Space : linked.opendata.cz associated with source document(s)

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Description	Structural and functional study of the cell nucleusMolecular embryology of the neural crest, of heart and circulatory system; developmental biologyStudy of glyciobiological characteristic of cells and tissues with respect on expression of endogenous lectins and reactive glycoligandsResearch into pathogenesis of the different types of gout with respect to renal impairment. (en) Výzkumný záměr reprezentuje dvanáct základních biomedicínských okruhů zaměřených na vybrané problémy normy a patologických stavů. Nadřazeným cílem je vzájemné sbližování biomedicínsky zaměřených pracovišť výzkumem na společné molekulární a buněčné úrovnmetodických center, jako nezbytný předpoklad pro perspektivní biomedicínský výzkum. Takto orientovaný výzkum je významným zdrojem relevantních informací o buněčných procesech operujících za normy a za patologických stavů a jejich poznání umožňuje vývoj nterapeutických postupů. Prioritou budou strukturně biologická studia jaderného kompartmentu, zejména popis jadérkové struktury z hlediska syntézy rRNA a replikace ribosomálních genů, studium dynamiky chromosomálních teritorií v souvislosti s jejich repliaanalýza vzájemné polohy chromosomů v jádře, analýza posice „linker“ histonu v chromatinovém vlákně, studium funkce Cajalova tělíska a jaderných skvrn, modifikace a remodelace chromatinu v regulaci transkripce, identifikace nových proteinů, které se pod
Title	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Studies at the molecular and cellular levels in normal and in selected clinically relevant pathologic states (en)
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http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33097079
http://linked.open...ai/cez/hlavniObor	FA - Kardiovaskulární nemoci včetně kardiochirurgie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cez/klicovaSlova	Molecular embryology; neural crest; circulatory system; developmental biology (en)
http://linked.open...cez/partnerHlavni	1. lékařská fakulta
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http://linked.open...lneniVMinulemRoce	2011-01-26 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cez/prideleniPodpory/144%2F2010-31
http://linked.open.../vavai/cez/resort	Ministry of Education, Youth and Sports
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ez/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cez/vedlejsiObor	EB - Genetika a molekulární biologie
http://linked.open...ez/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Výzkumný záměr velkou měrou přispěl k rozvoji nových diagnostických metod závažných lidských onemocnění, především na úrovni molekularní genetiky. Tato přesná a včasná diagnóza se nepochybně již nyní pozitivně promítá do úspěšnosti použité léčby. Finanční podpora umožnila formovat týmy mladých, vysoce erudovaných odborníků. (cs) The research project allowed development of a set of new diagnostic methods of serious human diseases, first of all the molecular biology level. The new precise and prompt diagnosis has positively influened the successful rate of all treatments. The finantial support helped to establish teams of zoung, highly qualified researchers. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Mosaic tissue distribution of the tandem duplication of LAMP2 exons 4 and 5 demonstrates the limits of Danon disease cellular and molecular diagnostics Peptidové inhibitory imobilizované na magnetické nosiče a Sepharosu aplikované na separaci žaludečních aspartátových proteinas Cortisol levels in cerebrospinal fluid correlate with severity and bacterial origin of meningitis GM1 Gangliosidosis and Morquio B Disease: Expression Analysis of Missense Mutations Affecting the Catalytic Site of Acid beta-Galactosidase Využití Real-Time systému pro kvantifikaci RNA a jeho použití v molekulární psychiatrii Ledviny - Anatomicko histologický úvod Cross-talk between the catalytic core and the regulatory domain in cystathionine beta-synthase: study by differential covalent labeling and computational modeling. Fetal cells of mesenchymal origin in cultures derived from synovial tissue and skin of patients with rheumatoid arthritis Intravascular ultrasound assessment of coronary artery involvement in Fabry disease Cytokeratins 8 and 18 in adult human corneal endothelium Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca(2+) Influx Sensitive to Calcium Entry Inhibitors Exprese cholinacetyltransferázy a muskarinových M2 receptorů v srdečních síních potkanů kmene Sprague-Dawley a Lewis Účinek dvou typů stresu na expresi cholinacetyltransferázy a muskarinových M2 receptorů v srdečních síních potkanů s odlišnou aktivitou HPA osy TRPC6 gene variants in Czech adult patients with focal segmental glomerulosclerosis and minimal change disease Trichobilharzia Discharge box with regulated humidity 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity Mean of inactivation of pathogenic prions, photosensitizer for pathogenic prions inactivation and use of photosensitizer for inactivation of pathogenic prions. ZnO hedgehog-like structures for control cell cultivation Decontamination of human skin by low-temperature plasma produced by cometary discharge Endothelial quality of pre-cut posterior corneal lamellae for Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S): two-year outcome of manual preparation in an ocular tissue bank Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice Snížená denzita kostního minerálu u žen s roztroušenou sklerózou Methyl gallate as the framework for the construction of fluorous building blocks The Microbicidal Effect of Low-Temperature Plasma Generated by Corona Discharge: Comparison of Various Microorganisms on an Agar Surface or in Aqueous Suspension Plasma Jetlike Point-to-Point Electrical Discharge in Air and Its Bactericidal Properties The %22cometary%22 discharge, a possible new type of DC electric discharge in air at atmospheric pressure, and its bactericidal properties Postoperative Epidural Fibrosis Embryogenesis of the heart muscle Abnormal myocardial and coronary vasculature development in experimental hypoxia Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development Differential Regulation of Galectin Expression/Reactivity during Wound Healing in Porcine Skin and in Cultures if Epidermal Cells with Functional Impact on Migration Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick Bendiocarb effect on liver and central nervous system in the chick embryo A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail Cultivation of human keratinocytes without feeder cells on polymer carriers containing ethoxyethyl methacrylate: in vitro study Immobilized metal affinity chromatography of phosphorylated proteins using highperformance sorbents Study of pepsin phosphorylation using immobilized metal affinity chromatography The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering Diamond seeding and growth of hierarchically structured films for tissue engineering Cystathionine .gamma.-lyase: Clinical, metabolic, genetic, and structural studies Semisynthesis of C17:0 isoforms of sulphatide and glucosylceramide using immobilised sphingolipid ceramide N-deacylase for application in analytical mass spectrometry Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours HIF and reactive oxygen species regulate oxidative phosphorylation in cancer Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells TRAIL-induced apoptosis of HL60 leukemia cells: Two distinct phenotypes of acquired TRAIL resistance that are accompanied with resistance to TNFa but not to idarubicin and cytarabine Chromatin position in human HepG2 cells: Although being non-random, significantly changed in daughter cells Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA Mesothelial proteins are expressed in the human cornea The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies Pontin is localized in nucleolar fibrillar centers Clinical implications of a close vicinity of nervus dorsalis penis/clitoridis and os pubis Gender reassignment surgery in male-to-female transsexualism: A retrospective 3-month follow-up study with anatomical remarks Role of matrix metalloproteinases in recurrent corneal melting Methodical approaches in the identification of areas with a potential risk of infection by bird schistosomes causing cercarial dermatitis Elevated lactate is a reliable marker pointing to mitochondrial disorders even in children after brief seizures. Study of urinary proteomes in Anderson-Fabry disease Sequential analysis of biomarkers in cerebrospinal fluid and serum during invasive meningococcal disease. Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease N-acetyl cysteine averted liver transplantation in a patient with liver failure caused by erythropoietic protoporphyria Useful Matlab tool for radio frequency designer Automatic Human Body Segmentation Using Mean-Shift Clustering As Assistance in The Hyperthermia Treatment Planning Restoration of Guyton´s Diagram for Regulation of the Circulation as a Basis for Quantitative Physiological Model Development Neisseria menigitidis strains from patients with invasive meningococcal disease differ in stimulation of cytoline production Anatomical study of position of the TVT-O to the obturator nerve influenced by the position of the legs during the procedure: based upon findings at formalin-embalmed and fresh-frozen bodies

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