About: The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice

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About: The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s11302-012-9340-5
Description	This study continues our earlier findings on the hematopoiesis-modulating effects of adenosine A(1) and A(3) receptor agonists that were performed on committed hematopoietic progenitor and precursor cell populations. In the earlier experiments, N (6)-cyclopentyladenosine (CPA), an adenosine A(1) receptor agonist, was found to inhibit proliferation in the above-mentioned hematopoietic cell systems, whereas N (6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agonist, was found to stimulate it. The topic of this study was to evaluate the possibility that the above-mentioned adenosine receptor agonists modulate the behavior of early hematopoietic progenitor cells and hematopoietic stem cells. Flow cytometric analysis of hematopoietic stem cells in mice was employed, as well as a functional test of hematopoietic stem and progenitor cells (HSPCs). These techniques enabled us to study the effect of the agonists on both short-term repopulating ability and long-term repopulating ability, representing multipotent progenitors and hematopoietic stem cells, respectively. In a series of studies, we did not find any significant effect of adenosine agonists on HSPCs in terms of their numbers, proliferation, or functional activity. Thus, it can be concluded that CPA and IB-MECA do not significantly influence the primitive hematopoietic stem and progenitor cell pool and that the hematopoiesis-modulating action of these adenosine receptor agonists is restricted to more mature compartments of hematopoietic progenitor and precursor cells. This study continues our earlier findings on the hematopoiesis-modulating effects of adenosine A(1) and A(3) receptor agonists that were performed on committed hematopoietic progenitor and precursor cell populations. In the earlier experiments, N (6)-cyclopentyladenosine (CPA), an adenosine A(1) receptor agonist, was found to inhibit proliferation in the above-mentioned hematopoietic cell systems, whereas N (6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agonist, was found to stimulate it. The topic of this study was to evaluate the possibility that the above-mentioned adenosine receptor agonists modulate the behavior of early hematopoietic progenitor cells and hematopoietic stem cells. Flow cytometric analysis of hematopoietic stem cells in mice was employed, as well as a functional test of hematopoietic stem and progenitor cells (HSPCs). These techniques enabled us to study the effect of the agonists on both short-term repopulating ability and long-term repopulating ability, representing multipotent progenitors and hematopoietic stem cells, respectively. In a series of studies, we did not find any significant effect of adenosine agonists on HSPCs in terms of their numbers, proliferation, or functional activity. Thus, it can be concluded that CPA and IB-MECA do not significantly influence the primitive hematopoietic stem and progenitor cell pool and that the hematopoiesis-modulating action of these adenosine receptor agonists is restricted to more mature compartments of hematopoietic progenitor and precursor cells. (en)
Title	The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice (en)
skos:prefLabel	The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice (en)
skos:notation	RIV/00216208:11110/13:10189444!RIV14-GA0-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA305/08/0158), P(GAP303/11/0128), P(LC06044), P(OVBIOFYZ20101), S, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Páral, Petr Savvulidi, Filipp Geirgievich Šefc, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	95999
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:10189444
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Long-term repopulating ability; Hematopoietic stem cells; IB-MECA; CPA; Adenosine receptor agonists (en)
http://linked.open.../riv/klicoveSlovo	Adenosine receptor agonists Long-term repopulating ability CPA IB-MECA Hematopoietic stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[275A3BFAE34E]
http://linked.open...i/riv/nazevZdroje	Purinergic Signalling
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	RECEPTOR - An agonist of adenosine A3 receptors in therapy of acute radiation diseas Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression Center for Experimental Hematology Role of adenosine A3 receptor signaling in regulation of hematopoiesis: knowledge obtained from adenosine A3 receptor knock-out mice
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hofer, Michal Hoferová, Zuzana Pospíšil, Milan Savvulidi, Filipp Geirgievich Šefc, Luděk Komůrková, Denisa Páral, Petr
http://linked.open...ain/vavai/riv/wos	000318559800008
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1573-9538
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11302-012-9340-5
http://localhost/t...ganizacniJednotka	11110

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