About: Microorganisms in Research and Biotechnology

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Zamer, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	Výzkum bude zaměřen na genomiku, proteomiku, bioinformatiku, fyziologii, stresové faktory, diferenciaci, morfologii, fylogenezi a ekologii mikroorganizmů včetně jejich biodegradačních aktivit a na mechanizmy jejich dlouhodobých adaptací k nepříznivým podmínkám. Dále budou studovány biotransformace, rekombinantní a transgenní mikrobní technologie. Šlechtěním a molekulárně genetickými metodami budou připravovány rekombinantní mikroorganizmy a v poloprovozních měřítkách získávány jejich produkty. U řas a bakterií budou studovány molekulární mechanizmy fotosyntetických procesů a fototrofická a heterotrofická reprodukce. Budou analyzovány molekulární aspekty bakteriální patogenicity, vrozené i získané imunitní reakce u konvenčních i bezmikrobních zvířat a jejich regulace za fyziologických a patologicky změněných podmínek. Pozornost bude věnována studiu a možnému ovlivnění autoimunitních reakcí a nádorových onemocnění, přípravě vakcín, protinádorových léčiv a imunoterapeutik. The research will be focused on genomics, proteomics, bioinformatics, physiology, stress factors, differentiation, morphology, phylogenesis and ecology of microorganisms including their biodegradation activities and mechanisms of long-term adaptations to adverse conditions. Biotransformations and recombinant and transgenic microbial technologies will also be studied and used to construct recombinant microorganisms, whose products will be obtained on a pilot plant scale. Molecular mechanisms of photosynthetic processes in both algae and bacteria and phototrophic and heterotrophic production of alge will also be studied. Molecular aspects of bacterial pathogenicity and innate and acquired immune response will be analyzed in conventional and germ-free animals. Attention will be paid to their regulation under physiological and pathologically modified conditions (autoimmune diseases, tumors) and new anti-tumor drugs and immunotherapeutics will be investigated. (en)
Title	Microorganisms in Research and Biotechnology (en) Mikroorganizmy ve výzkumu a biotechnologiích
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50200510/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z50200510/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ12-AV0-U%2F01%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33135862
http://linked.open...ai/cez/hlavniObor	EE - Mikrobiologie, virologie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	algae; antibiotics; autoimmune diseases; bacteria; bioinformatics; bioremediation; biotechnology; cancer; cell ultrastructure; enzymes; secondary metbolites; fungi; germ-free; immunology; microbiology; molecular biology; nanotechnology; streptomycetes; … (en)
http://linked.open...cez/partnerHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...z/poceVysledkuRIV	1611 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	1611 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-12-06 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cez/prideleniPodpory/AV0Z50200510
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ez/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cez/vedlejsiObor	EB - Genetika a molekulární biologie EC - Imunologie
http://linked.open...ez/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Výzkum byl zaměřen na genomiku, proteomiku, bioinformatiku, fyziologii a ekologii mikroorganismů včetně jejich biodegradačních aktivit. Dále byly studovány biotransformace, rekombinantní a transgenní mikrobní technologie. Byly analyzovány molekulární aspekty bakteriální patogenicity a regulace imunitních reakcí za fyziologických a patologicky změněných podmínek. (cs) The research was focused on the genomics, proteomics, bioinformatics, physiology, and ecology of microorganisms including their biodegradation activities. Biotransformation, recombinant as well as transgenic microbial technologies were studied. Molecular aspects of bacterial pathogenicity and regulation of immune reactions under physiological and pathological conditions were analyzed. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Hyphal growt and mycorrhiza formation by the arbuscular mycorrhizal fungus Glomus claroideum BEG 23 is stimulated by humic substances Nasal-associated lymphoid tissue (NALT) in NOD mice; local induction of Tregs after i.n. administration of an antigen Equipment for cultivation and complex processing of algal biomass rich in polysaccharides to bioethanol and nutrition/ feed supplement Gut mucosa and mucosal immunity as a gateway for autoimmunity in type 1 diabetes; the NOD mouse model Fine needle aspiration biopsy as a new method for monitoring of tumor microenvironment after treatment with polymeric drugs Genetic Control of Biosynthesis of Secondary Metabolites – Lincosamide Antibiotics as Examples Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Gamma-tubulin is required for cytokinesis and cell paterning in Arabidopsis Generation of volatile species of transition and noble metals by aqueous tetrahydroborate Omega1 subunit of RNA polymerase from Gram-positive bakteria Bacterial communities of two contrasting soils reacted differently to lincomycin treatment Subunit-subunit interactions are weakened in mutant forms of acetohydroxy acid synthase insensitive to valine inhibition Optimised acidification power test of yeast vitality and its use in brewing practice Hydrolysis of benzonitrile herbicides by soil actinobacteria and metabolite toxicity Hopanoids in Bacteria and Cyanobacteria ? Their Role in Cellular Biochemistry and Physiology, Analysis and Occurrence. Autocrine effects of visfatin on hepatocyte sensitivity to insulin action. VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in apoE-deficient mice fed standard low cholesterol diet Synchronous plasma membrane electrochemical potential oscillations during yeast colony development and aging. 14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4 Toward a revision of the genus Synura, section Petersenianae (Synurophyceae, Heterokontophyta): morphological characterization of six pseudo-cryptic species Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum Účast slizničního imunitního systému a komensálních bakterií v alergii Beta-tubulin paralogue tubC is frequently misidentified as the benA gene in Aspergillus section Nigri taxonomy: primer specificity testing ad taxonomic consequences Biodegradation of phenol using recombinant plasmid-carrying Rhodococcus erythropolis strains Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family Lipophosphonoxins, method of their preparation and use Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells Determination of 8-iso-prostaglandin F2 in exhaled breath condensate using combination of immunoseparation and LC-ESI-MS/MS Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens Rapid and easy method for monitoring oxidative stress markers in body fluids of patients with asbestos or silica-induced lung diseases The mechanism of gingiva metallic pigmentations formation LC-ESI-MS/MS method for oxidative stress multimarker screening in the exhaled breath condensate of asbestosis/silicosis patients The influence of operating conditions on the efficiency of vapor phase hydrogen peroxide in the degradation of 4-(dimethylamino)benzaldehyde The study of vapour phase hydrogen peroxide decontamination process as a potential method for degradation of organic pollutants Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis. The intestinal microflora of childhood patients with indicated celiac disease Terapeutická a patologická fúze nádorových buněk s imunitními buňkami - nádorové vakcíny versus nádorové hybridy Report. 1st Central and Eastern European Proteomic Conference and 3rd Czech Proteomic Conference Bifidobacterium bombi sp. nov., a new bifidobacterium from the bumblebee digestive tract Targed neural stem cell differentiation and related cell based therapy in spinal cord injury In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome Effect of anti-cancer drug cis-platin on leukemia cells-protein profiling using three independent analytical techniques Multivariate statistical analysis for anti-cancer drug treatment evaluation Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques Imunomodulační efekt bakteriálního lyzátu Lactobacillus Casei DN 1140001 na vznik a vývoj experimentálně vyvolaného střevního zánětu Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization HPMA copolymer conjugates for dual therapy Polymer drug carriers for passive and active tumour targeting N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and preliminary biological evaluation Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity Thermoresponsive hydrolytically degradable polymer micelles intended for radionuclide delivery HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides The high resolution structure of the extracellular domain of human CD69 using a novel polymer Biological evaluation of polymeric micelles with covalently bound doxorubicin High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: Efficacy, safety and immunomodulating activity in murine model HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release Polyoxazoline thermoresponsive micelles as radionuclide delivery systems Micellar and antibody-targeted polymer therapeutics Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through and amide or hydrazone bond HPMA – Anticancer Drug Conjugates

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