About: Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio

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About: Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Antimicrobial drugs that target directly the cell surface structures, resulting in cell permeabilization, were screened by our fluorescence method based on the use of the potentiometric fluorescent probe diS-C3(3). DiS-C3(3) is a substrate for two major S. cerevisiae MDR pumps, Pdr5p and Snq2p. Its use represents an efficient strategy for identifying pump inhibitors with minimal side effects on membrane potential or membrane integrity, and for detecting cells permeabilized by surface active drugs. The screening is performed on cells in well-defined physiological state and does not require any pretreatment or preincubation Antimicrobial drugs that target directly the cell surface structures, resulting in cell permeabilization, were screened by our fluorescence method based on the use of the potentiometric fluorescent probe diS-C3(3). DiS-C3(3) is a substrate for two major S. cerevisiae MDR pumps, Pdr5p and Snq2p. Its use represents an efficient strategy for identifying pump inhibitors with minimal side effects on membrane potential or membrane integrity, and for detecting cells permeabilized by surface active drugs. The screening is performed on cells in well-defined physiological state and does not require any pretreatment or preincubation (en)
Title	Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio (en)
skos:prefLabel	Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio Fast estimation of modes of action of antimicrobials on yeast Saccharomyces cerevisiae - from MDR pump inhibition with a minimal effect on membrane potential up to cell permeabilizatio (en)
skos:notation	RIV/61388971:_____/09:00340980!RIV10-MSM-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0570), Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Sigler, Karel Gášková, Dana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	314695
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/09:00340980
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mdr pump (en)
http://linked.open.../riv/klicoveSlovo	mdr pump
http://linked.open...ontrolniKodProRIV	[89DF71459FBF]
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Research Centre for Study of Extract Compounds of Barley and Hop
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Sigler, Karel Gášková, Dana Kodedová, M. Hendrych, T. Drietomská, A.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology

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