About: Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae accounts for serious economic losses in the pig farming industry worldwide. We examined here the immunogenicity and protective efficacy of the recombinant type IV fimbrial subunit protein ApfA as a single antigen vaccine against pleuropneumonia, or as a component of a multi-antigen preparation comprising five other recombinant antigens derived from key virulence factors of A. pleuropneumoniae (ApxIA, ApxIIA, ApxIIIA, ApxIVA and TbpB). Immunization of pigs with recombinant ApfA alone induced high levels of specific serum antibodies and provided partial protection against challenge with the heterologous A. pleuropneumoniae serotype 9 strain. This protection was higher than that engendered by vaccination with rApxIVA or rTbpB alone and similar to that observed after immunization with the tri-antigen combination of rApxIA, rApxIIA and rApxIIIA Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae accounts for serious economic losses in the pig farming industry worldwide. We examined here the immunogenicity and protective efficacy of the recombinant type IV fimbrial subunit protein ApfA as a single antigen vaccine against pleuropneumonia, or as a component of a multi-antigen preparation comprising five other recombinant antigens derived from key virulence factors of A. pleuropneumoniae (ApxIA, ApxIIA, ApxIIIA, ApxIVA and TbpB). Immunization of pigs with recombinant ApfA alone induced high levels of specific serum antibodies and provided partial protection against challenge with the heterologous A. pleuropneumoniae serotype 9 strain. This protection was higher than that engendered by vaccination with rApxIVA or rTbpB alone and similar to that observed after immunization with the tri-antigen combination of rApxIA, rApxIIA and rApxIIIA (en)
Title	Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia (en)
skos:prefLabel	Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia (en)
skos:notation	RIV/61388971:_____/12:00377903!RIV13-GA0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FT-TA2/025), P(GAP207/11/0717), P(GAP302/11/0580), P(KAN200520702), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Osička, Radim Šebo, Peter Sadílková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	175532
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/12:00377903
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ApfA; immunogenicity; virulence factors (en)
http://linked.open.../riv/klicoveSlovo	ApfA virulence factors immunogenicity
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[97EA82BA77AE]
http://linked.open...i/riv/nazevZdroje	Veterinary Research
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	*Development of cultivation and purification technologies for industrial production of recombinant vaccines. Molecular mechanism of autocatalytic protein splicing of the RTX protein FrpC from Neisseria meningitidis Interaction of adenylate cyclase toxin with complement receptor 3 Nanoimmunosensors for detection of cytokines
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Osička, Radim Šebo, Peter Sadílková, Lenka Nepeřený, J. Vrzal, V.
http://linked.open...ain/vavai/riv/wos	000300508600001
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0928-4249
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1297-9716-43-2
is http://linked.open...avai/riv/vysledek of	Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

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