About: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators

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About: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=ONVLAJEP20031
Description	The aim of this project is synthetizing, in vitro and in vivo testing of new acetylcholinesterase reactivators that will be effective enough for treatment of cyclosin intoxication. Potentially effective compounds will be chosen from original structures proposed at our department based on long-term experiences with reactivating oximes. (en) Cílem projektu je nasyntetizovat a in vitro a in vivo otestovat takové reaktivátory AChE, které by byly dostatečně efektivní při terapii otrav cyklosinem. Potenciálně účinné sloučeniny budou vybírány z originálních struktur navržených na našem pracovišti, které byly sestaveny na základě dlouholetých zkušeností v oblasti reaktivujících oximů.
Title	New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators (en) INTOXIKACE - Nové možnosti terapie intoxikací cyklosinem: syntéza a testování nových reaktivátorů acetylcholinesterázy
skos:notation	ONVLAJEP20031
http://linked.open...avai/cep/aktivita	National research scheme in the sphere of safety and defence (2001-2004)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/ONVLAJEP20031/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/ONVLAJEP20031/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2006-06-21 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	33677172
http://linked.open...ai/cep/hlavniObor	FP - Ostatní lékařské obory
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open...vai/cep/kategorie	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cep/klicovaSlova	acetylcholinesterase reactivators;cyclosin intoxication;oximes (en)
http://linked.open...ep/partnetrHlavni	Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	52 (xsd:int)
http://linked.open...enychVysledkuVRIV	52 (xsd:int)
http://linked.open...okUkonceniPodpory	2005
http://linked.open...okZahajeniPodpory	2003
http://linked.open...iciPoslednihoRoku	2006
http://linked.open...atUdajeProjZameru	2006
http://linked.open.../vavai/cep/soutez	SMO0200391001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	KA - Vojenství
http://linked.open...jektu+dodavatelem	Both, in vitro (reactivation tests), as well as in vivo results (therapeutic efficacy, neurotoxicity testing) show, that the most effective oxime in the treatment of cyclosarin intoxications is HI-6 oxime. (en) Na základě výsledků dosažených jak in vitro (reaktivační testy), tak in vivo (terapeutická účinnost, hodocení neurotoxicity) je nejúčinnějším oximem v terapii otrav cyklosarinem oxim HI-6. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	acetylcholinesterase reactivators cyclosin intoxication
is http://linked.open...vavai/riv/projekt of	Current position of cyclosarin New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 A general method for the quaternization of N,N-dimethyl benzylamines with long chain n-alkylbromides Acetylcholinesterase: crucial enzyme of human body Nově vyvinuté oximy - K005, K033, K027 a K048 a jejich schopnost reaktivovat látkou VX inhibovanou acetylcholinesterázu Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators Cyclosarin-an organophosphate nerve agent Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase In-vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent Ověření vhodnosti insekticidu chlorpyrifos jako simulantu nervově paralytických látek metodou in vitro Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase Synthesis of bispyridinium compounds bearing propane linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase Syntéza reaktivátorů fosforylované acetylcholinesterasy bis-pyridiniumdialdoximového typu s 3-oxapentanovým spojovacím řetězcem a jejich testování in vitro na modelu enzymu inhibovaného chlorpyrifosem a methylchlorpyrifosem Structural requirements of acetylcholinesterase reactivators Přiřazení struktur reaktivátorů organofosfáty-inhibované acetylcholinesterázy na základě spekter nukleární magnetické rezonance Progress in synthesis of new acetylcholinesterase reactivators during the period 1990-2004 Metody umělé inteligence: nový trend ve farmacii Prediction of a new broad-spectrum reactivator capable to reactivate acetylcholinesterase inhibited by nerve agents Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings Synthesis of the novel series of bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase Synthesis of the novel series of bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase Synthesis of the novel AChE reactivators and their ability to reactivate in vitro chlorpyrifos-inhibited AChE Bispyridinium oximes as antidotal treatment of cyclosarin poisoning - in vitro and in vivo testing Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes What are artificial neural networks and what they can do ? Changes of acetylcholinesterase activity after long-term exposure to sarin vapors in rats Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin Progress in synthesis of new acetylcholinesterase reactivators in period 1990-2004 In vitro reactivation potency of some acetylcholinesterase reactivators against sarin and cyclosarin-induced inhibitions In vitro reactivation of sarin-inhibited brain acetylcholinesterase from various species by various oximes Optimalization of synthesis of new acetylcholinesterase reactivators - K027 and K048 Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes Quaternary heteroarenium salts as the competitive inhibitors of the brain acetylcholinesterase Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes Testování nových reaktivátorů acetylcholinesterázy při terapii otrav cyklosarinem Synthesis of bisquaternary symmetric - c,d-bis(2-hydroxyiminomethylpyridinium)alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice Therapeutic efficacy of oxime treatment in cyclosarin-poisoned mice pretreated with combination of pyridostigmine, benactyzine and trihexyphenidyl Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods New quaternary pyridine aldoximes as causal antidotes against nerve agents intoxications New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/ONVLAJEP20031/2003/orjk%3AG44 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/ONVLAJEP20031/2004/orjk%3AG44 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/ONVLAJEP20031/2005/orjk%3AG44 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/ONVLAJEP20031/2006/orjk%3AG44

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