| Attributes | Values |
|---|
| rdf:type
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| Description
| - V této práci byly testovány nové reaktivátory AChE (Korea, Daejon # KRICT) pro jejich schopnost reaktivovat AChE inhibovanou nervově paralytickými látkami # tabun a cyklosarin (cs)
- Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed.Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxy
- Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed.Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxy (en)
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| Title
| - In vitro zhodnocení nových reaktivátorů acetylcholinesterázy jako kauzálních antidot proti tabunu a cyklosarinu (cs)
- In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin
- In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin (en)
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| skos:prefLabel
| - In vitro zhodnocení nových reaktivátorů acetylcholinesterázy jako kauzálních antidot proti tabunu a cyklosarinu (cs)
- In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin
- In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin (en)
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| skos:notation
| - RIV/60162694:G44__/06:00001491!RIV07-MO0-G44_____
|
| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(OBVLAJEP20032), P(ONVLAJEP20031)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/06:00001491
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Acetylcholinesterase reactivators; Antidote; Organophosphorus intoxication; Cyclosarin; Tabun; Oxime (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Bulletin of the Korean Chemical Society
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Kuča, Kamil
- Jun, Daniel
- Jung, Y. S.
- Kim, T. H.
|
| issn
| |
| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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