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| Description
| - The study of basic biological (toxic) effects of tabun with the help of experiments using small laboratory animals and involving biochemical, pharmacological and behavioral methods to observe tabun-induced changes in basic physiological function (respiration, circulaton), activity of basic biochemical marker of nerve agents exposure (acetylcholinesterase activity) in the blood and organs and to follow the signs of neurotoxicity of tabun including tabun-induced changes in cognitive functions. Histochemical and imunocytochemical analyses of tissue samples. The evalluation of the efficacy of prophylactic and therapeutic antidotes and their combinations against acute toxic effects of tabun with the help of above mentioned methods to find the most efficacious combination of antidotes for pretreatment and treatment of acute tabun poisonings. (en)
- Studium základních biologických (toxikologických) účinků tabunu pomocí experimentu na malém laboratorním zvířeti pomocí biochemických, farmakologických a neurobehaviorálních metod se zaměřením na sledování změn základních fyziologických funkcí (dýchání,krevní oběh), změn aktivity základního biochemického ukazatele otravy NPL aktivity acetylcholinesterázy v krvi a orgánech, na sledování neurotoxicity tabunu včertně vlivu na kognitivní funkce. Histochemická a imunocytochemická analýza vzorků tkání. Vyhodnocení účinku různých profylakticky či terapeuticky podaných antidot a jejich kombinací proti akutním toxickým účinkům tabunu pomocí výše uvedených metod za účelem nalezení co nejúčinnější kombinace antidot k profylaxi a terapii otrav tabunem.
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| Title
| - C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents (en)
- C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Tabun; respiration; circulaton; biochemical marke; nerve agents; acetylcholinesterase activity (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Trimedoxime seems to be the most efficacious currently available reactivator of acetylcholinesterase for the treatment of acute tabun poisonings. The decontamination means containing ketoximes or aldoximes are not useful because of late phosphorylation. (en)
- Trimedoxim se jeví jako nejúčinnější dostupný reaktivátor acetylcholinesterázy pro terapii akutních otrav tabunem. Odmořovací činidla obsahující ketoximy či aldoximy nejsou z důvodu pozdní fosforylace použitelná. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - nerve agents
- respiration
- biochemical marke
- circulaton
- Tabun
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| is http://linked.open...vavai/riv/projekt
of | - Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents
- Prophylaxis of nerve agents intoxication. The results of a clinical study
- The influence of the time of antidotal treatment administration on its effectiveness against tabun-induced poisoning in mice
- In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
- In vitro reactivation of acetylcholinesterase using the oxime K027
- Specification of the structure of oximes able to reactivate tabun - inhibited acetylcholinesterase
- Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
- Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibitied by paraoxon
- A Comparison of the Ability of a New Bispyridinium Oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase by In Vitro Methods
- Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats
- Acute experimental tabun-induced intoxication and its therapy in rats
- A comparison of the efficacy of a bispyridinium oxime - 1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
- Farmakologická profylaxe a antidotní terapie akutní otravy tabunem
- Determination of benzalkonium bromide homologues in desinfection products using high-performance liquid chromatography
- Comparison of effects of different antidotes on tabun-induced cognitive impairment in rats using water maze
- Sarafotoxiny
- Pharmacological potential of endothelin receptors agonists and antagonists
- Kyselina domoová, nebezpečný neurotoxin
- Otravné látky dráždivé
- Structural requirements of acetylcholinesterase reactivators
- Comparison of changes in AChE activity in the brain of the laboratory rat after soman and tabun intoxication
- Azaspiracid: a new marine toxin
- Effective bisquaternary reactivators of tabun-inhibited AChE
- A comparison of the efficasy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods
- Pretreatment with L-carnitine enhanced acetylcholinesterase inhibition following Galanthamine administration in rats
- Prediction of a new broad-spectrum reactivator capable to reactivate acetylcholinesterase inhibited by nerve agents
- Comparison of efficacy acetylcholiesterase reactivators inhibited by tabun
- Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings
- Three awards, three generations
- Anticholinesterase effect of gallanthamine influenced by L-carnitine
- Chemical war history with chlorine, phosgene and mustard gas deployment
- The role of oximes in the antidotal treatment of chemical casualties exposed to nerve agents
- Vliv dávky reaktivátorů acetylcholinesterázy na jejich účinnost při terapii otravy myší tabunem
- The effect of repeated antidotal treatment on tabun-induced toxicity in mice
- Complex view on poisoning with nerve agents and organophosphates
- Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo
- Chlor nás příliš často děsí
- Comparison of the efficacy of currently available oximes against tabun in rats
- Testing of decontamination efficacy of decontamination gloves with DESPRACH
- A comparison of the potency of newly developed oximes (K027, K048) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity
- A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods
- The influence of oxime and anticholinegic drug selection on the potency of antidotal treatment to counteract acute toxic effects of tabun in mice
- The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze
- In vitro evaluation of new acetylcholinesterase reactivators as casual antidotes against tabun and cyclosarin
- In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
- The influence of the time of antidotal treatment administration on the potency of newly developed oximes to counteract acute toxic effects of tabun in mice
- In vitro reactivation of sarin-inhibited brain acetylcholinesterase from various species by various oximes
- Laboratory diagnosis of organophosphate/nerve agent poisoning
- L'humanité a peur du chlore depuis 90 ans déja
- Organophosphate poisoning: possibilities of prophylaxis
- Optimalization of synthesis of new acetylcholinesterase reactivators - K027 and K048
- Oxime reactivation of acetylcholinesterase inhibited by toxic phosphorus ester: In vitro kinetics and thermodynamics
- Omamné a psychotropní látky - metodologie profesních testů pro potřeby Armády České republiky
- Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro
- The influence of acetylcholinesterase reactivator selection on the elimination of tabun-induced signs of neurotoxicity in rats
- Synthesis of a new reactivator of tabun inhibited acetylcholinesterase
- Anticholinergic drugs-functional antidotes for the treatment of tabun intoxication
- Changes of some physiological parameters following administration of PANPAL in healthy volunteers
- Prophylactic antidotes against nerve agents in the Czech Army (PANPAL and TRANSANT)
- A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun
- A complex process of the development of new acetylcholinesterase reactivators - from prediction to in vivo evaluation
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