About: New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are compounds, which are able to treat intoxication with organophosphorus compounds, especially with pesticides or nerve agents. Owing to the fact that there exist no universal %22broad-spectrum%22 reactivator of oranophosphates-inhibited AChE, many laboratories from the world synthesize new AChE reactivators. In our work, there were synthesized five new and three already known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerve agents. Potencies to cleave p-nitrophenyl acetate (PNPA), which is commonly used as model substrate of the nerve agents, were measured. Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). Three newly synthesized oximes achieved similar nuclephilicity at the similar pKa according to 4-PAM, what is very promi Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are compounds, which are able to treat intoxication with organophosphorus compounds, especially with pesticides or nerve agents. Owing to the fact that there exist no universal %22broad-spectrum%22 reactivator of oranophosphates-inhibited AChE, many laboratories from the world synthesize new AChE reactivators. In our work, there were synthesized five new and three already known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerve agents. Potencies to cleave p-nitrophenyl acetate (PNPA), which is commonly used as model substrate of the nerve agents, were measured. Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). Three newly synthesized oximes achieved similar nuclephilicity at the similar pKa according to 4-PAM, what is very promi (en)
Title	New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents (en)
skos:prefLabel	New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents (en)
skos:notation	RIV/60162694:G44__/05:00001349!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Cabal, Jiří Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	532687
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/05:00001349
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acetylcholinesterase; Reactivator; PNPA; Reactivation; Nerve agents; Inhibition (en)
http://linked.open.../riv/klicoveSlovo	PNPA Inhibition Reactivation Acetylcholinesterase Nerve agents Reactivator
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[80DE0CE5DF83]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Liška, F. Kohout, M. Pícha, J. Kivala, M.
http://linked.open...ain/vavai/riv/wos	000230820000004
issn	1475-6366
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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