About: The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oximes in combination with atropine, are an integral part of the treatment of acute intoxications with organophosphorus insecticides or with the nerve agents such as tabun, sarin, soman, cyclosarin or VX. Organophosphorus compounds are extremely potent inhibitors of the enzyme acetylcholinesterase (AChE, 3.1.1.7). The pharmacological action of oximes is multiple: they are able to reactivate the inhibited AChE, but they affect acetylcholine release in peripheral and central cholinergic synapses, allosterically modulate the muscarinic receptors in peripheral and central synapses and influence the nicotinic receptor associated ion-channels. In our study, we have determined the acute toxicity of different structures of oximes after intramuscular application in mice. The acute toxicity of oximes is crucial for the assesment of a dose applied as a treatment for organophosphorus intoxications. We have tested 7 oximes of different structures (HS-6, K033, BI-6, MMB-4, K048, HI-6 and obidoxime) and during exper Oximes in combination with atropine, are an integral part of the treatment of acute intoxications with organophosphorus insecticides or with the nerve agents such as tabun, sarin, soman, cyclosarin or VX. Organophosphorus compounds are extremely potent inhibitors of the enzyme acetylcholinesterase (AChE, 3.1.1.7). The pharmacological action of oximes is multiple: they are able to reactivate the inhibited AChE, but they affect acetylcholine release in peripheral and central cholinergic synapses, allosterically modulate the muscarinic receptors in peripheral and central synapses and influence the nicotinic receptor associated ion-channels. In our study, we have determined the acute toxicity of different structures of oximes after intramuscular application in mice. The acute toxicity of oximes is crucial for the assesment of a dose applied as a treatment for organophosphorus intoxications. We have tested 7 oximes of different structures (HS-6, K033, BI-6, MMB-4, K048, HI-6 and obidoxime) and during exper (en) Byla testována akutní toxicita 7 strukturně odlišných reaktivátorů AChE (HS-6, K033, BI-6, MMB-4, K048, HI-6 and obidoxim). Strukturní vlastnosti hrají důležitou roli v biologické aktivitě reaktivátorů AChE. (cs)
Title	Akutní toxicita reaktivátorů acetylcholinesterázy na myších ve vztahu k jejich struktuře (cs) The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure (en)
skos:prefLabel	Akutní toxicita reaktivátorů acetylcholinesterázy na myších ve vztahu k jejich struktuře (cs) The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure (en)
skos:notation	RIV/60162694:G44__/06:00001473!RIV07-MO0-G44_____
http://linked.open.../vavai/riv/strany	291-296
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Bartošová, Lucie Jun, Daniel Kuča, Kamil Kunešová, Gabriela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	464108
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/06:00001473
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Oxime; Mice; Acute toxicity; Acetylcholinesteraese (en)
http://linked.open.../riv/klicoveSlovo	Mice Acute toxicity Oxime Acetylcholinesteraese
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DADAA7A2E2CD]
http://linked.open...i/riv/nazevZdroje	Neurotoxicity Research
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Jun, Daniel Bartošová, Lucie Kunešová, Gabriela
issn	1029-8428
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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