About: In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048

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About: In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048 (cs) We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators - K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide), K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide) as the potential reactivators of AChE inhibited by cyclosarin. Their reactivation potencies were studied using standard in vitro reactivation test. Rat brain homogenate was used as the source of the enzyme. Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of all other tested AChE reactivators. We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators - K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide), K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide) as the potential reactivators of AChE inhibited by cyclosarin. Their reactivation potencies were studied using standard in vitro reactivation test. Rat brain homogenate was used as the source of the enzyme. Oxime K033 seems to be the most potent reactivator of cyclosarin-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of all other tested AChE reactivators. (en)
Title	In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048 (cs) In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 (en)
skos:prefLabel	In vitro reaktivace acetylcholinesterazy inhibované cyklosarinem užitím biskvartérních aldoximů K005, K033, K027 a K048 (cs) In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 and K048 (en)
skos:notation	RIV/60162694:G38__/04:00001082!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	107-109
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	567629
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/04:00001082
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyclosarin;in vitro;reactivation;inhibition;acetylcholinesterase;K005;K033;K027;K048;oximes;nerve agents;GF agent;cyclosin (en)
http://linked.open.../riv/klicoveSlovo	GF agent K005 cyclosin inhibition nerve agents oximes K027 K033 acetylcholinesterase reactivation in vitro K048 Cyclosarin
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0E7D1BF951AE]
http://linked.open...i/riv/nazevZdroje	Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Ševelová-Bartošová, Lucie Krejčová-Kunešová, Gabriela
issn	1211-4286
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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