About: Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators     Goto   Sponge   NotDistinct   Permalink

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Description
  • New bis-pyridinium oxime reactivators connected with a CH2CH2OCH2CH2 linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10 % at the lower concentration 10-4 M.
  • New bis-pyridinium oxime reactivators connected with a CH2CH2OCH2CH2 linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10 % at the lower concentration 10-4 M. (en)
  • Popsán design a syntéza nových bispyridiniových oximů jako reaktivátorů acetylcholinesterázy inhibované cyklosarinem. (cs)
Title
  • Design a syntéza nových bispyridiniových oximů jako reaktivátorů acetylcholinesterázy inhibované cyklosarinem (cs)
  • Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators
  • Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators (en)
skos:prefLabel
  • Design a syntéza nových bispyridiniových oximů jako reaktivátorů acetylcholinesterázy inhibované cyklosarinem (cs)
  • Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators
  • Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators (en)
skos:notation
  • RIV/60162694:G44__/05:00001297!RIV06-MO0-G44_____
http://linked.open.../vavai/riv/strany
  • 2914-2917
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika
  • 0
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 517366
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/05:00001297
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Orgahophosphorus nerve agents; Bis-pyridinium oxime reactivatiors; Inhibition; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [CFA1D188BDEF]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Kuča, Kamil
  • Jun, Daniel
  • Jung, Y. S.
  • Kim, T. H.
issn
  • 0960-894X
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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