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| Description
| - The project will develop the knowledge obtained in succesful previous aimed research focused on describing the effects of unsaturated fatty acids and components of phospholipid metabolism in a way enabling publication in renowned journals. Mechanisms of the effects of these substances and lipid emulsions in cell signalling regulating proliferation, differentiation, apoptosis and physiological cell functions will be studied in models comprising normal and malignant cells of the haemopoietic and immune system, hepatic and intestinal epithelial cells both in vitro and in vivo. A wide spectrum of modern methods of molecular biology, and, further e.g., confocal microscopy, multiparametric flow-cytometry, and transplantation techniques In a tight cooperation of the applicant and INFUSIA, Hořátev, new data important from the point of view of innovations of infusion solutions having the perspective of applicability at specific diagnoses (disease specific nutrition) will be obtained. (en)
- Bude navázáno na dřívější úspěšné grantové aplikace z oblasti cíleného výzkumu zaměřeného na poznání účinků nenasycených mastných kyselin a složek fosfolipidového metabolismu. Výsledky budou publikovány v renomovaných časopisech. Na modelech, zahrnujících normální i nádorové buňky krvetvorného a imunitního systému, buňky jater a střevních epitelů jak in vitro tak in vivo, budou studovány mechanismy působení výše uvedených látek (později i vzorků emulzí) na signální dráhy regulující proliferaci, diferenciaci, apoptózu a základní fyziologické buněčné funkce. Bude využita škála moderních metodik molekulární biologie (a další metody jako konfokální mikroskopie, multiparametrická flow cytometrie, transplatační metody apod.). V těsné kooperaci tří laboratoří BFÚ AVČR v Brně a INFUSIA a.s., Hořátev bude cílem získat poznatky důležité pro inovace infusních roztoků a perspektivně aplikovatelné u specifických diagnóz (disease specific nutrition).
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| Title
| - Lipid nutrition compounds - modulation of their effects and possibilities of practical application (en)
- Tukové složky výživy - modulace jejich účinků a možnosti praktického využití
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - lipid emulsions in nutrition; fatty acids; eikosanoids; lipid peroxides; reactive oxygen and nitrogen metabolites; hepatocytes; hematopoietic cells; cells of immune systém; tumor cells; proliferation; differentiation; apoptosis; cytokinetics (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Poznatky o mechanismech působení lipidových složek diety a nových Pt komlexů přispěly k a) pochopení jejich úlohy v řízení cytokinetiky normálních a nádorových buněk, b) optimalizaci složení lipidových nutričních doplňků a protinádorové terapie. (cs)
- Knowledge of the effects of lipid components and new Pt complexes contributed to i/understanding of their role in regulation of cytokinetics of normal and cancer cells, ii/ optimization of the composition of nutritional supplements and anticancer therapy (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - apoptosis
- differentiation
- fatty acids
- hepatocytes
- proliferation
- tumor cells
- cells of immune systém
- eikosanoids
- hematopoietic cells
- lipid peroxides
- reactive oxygen and nitrogen metabolites
- lipid emulsions in nutrition
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| is http://linked.open...vavai/riv/projekt
of | - Comparative investigations of the influence of H1-antihistamines on the generation of reactive oxygen species by phagocytes
- Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells
- Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines
- Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy
- Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism
- The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation
- Effect of carvedilol on the production of reactive oxygen species by HL-60 cells
- Interaction of dietary short- and long-chain fatty acids influencing differentiation and apoptotic response in colon epithelial cells
- Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin
- The effects of dithiaden on nitric oxide production by RAW 264.7 cells
- Inhibition of cyclooxygenase 2 in mice increases production of G-CSF and induces radioprotection
- Meloxicam elevates serum concentration of Erythropoietin and numbers of bone marrow erythroid progenitor cells in sublethally gamma-irradiated mice
- Carvedilol and adrenergic agonists suppress the lipopolysaccharide-induced NO production in RAW 264.7 macrophages via the adrenergic receptors
- The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity
- Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
- 5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway
- Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs
- Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs
- Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines
- Phagocyte-derived oxidants and plasma antioxidants in haemodialysed patients
- Continuous electrochemical monitoring of nitric oxide production in murine macrophage cell line RAW 264.7
- Different methods for control and comparison of the antioxidant properties of vegetables
- Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation
- Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex
- Transforming growth factor-beta 1 inhibits all-trans retinoic acid-induced apoptosis
- Increased antioxidant capacity of serum did not prevent lipid peroxidation in the intermittent ischemia-reperfusion of rat small intestine
- Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines
- Induction of expression of nag-1/MIC-1/GDF-15 in prostate and colon epithelial inflammatory drugs
- Meloxicam, a cyclooxygenase 2 inhibitor, supports hematopoietic recovery in gamma-irradiated mice
- Comparative determination of apoptotic markers detected by flow cytometry and correlation with other methods
- High effectiveness of novel platinum derivative with adamantylamine LA-12 and possible mechanisms of its action
- Analytical cytometry in the Czech Republic: Perspectives and possibilities of co-operation in centralEUROPE
- Different response of normal and cancer colonic epithelial cells to butyrate and polyunsaturated fatty acids
- Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells
- Accumulation of chloroplast DNA sequences on the Y chromosome of Silene latifolia
- MK17, a specific marker closely linked to the gynoecium suppression region on the Y chromosome in Silene latifolia
- Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin
- Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin
- Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells
- Lipid changes in normal and cancer colon cells during differentiation and apoptosis induced by fatty acids
- Inhibition of cyclooxygenase-2 by meloxicam supports hematopoiesis
- Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin
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| is http://linked.open...vavai/cep/projekt
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