About: Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tento článek je zaměřen na úlohu reaktivních kyslíkových metabolitů tvořených neutrofily v iniciaci lipidové peroxidace. Oxidace lipidů je považována za typický znak chronického a akutního zánětu. Avšak oxidace biologicky aktivních prozánětlivých lipidů může mít protizánětlivý účinek a tím přispívat k ukončení zánětlivého procesu. Tudíž peroxidace lipidů způsobená reaktivními metabolity neutrofilů, může jak potenciovat, tak redukovat zánětlivou reakci. Pro správnou kontrolu fyziologické zánětlivé odpovědi je potřeba tyto procesy držet v jemné rovnováze. (cs) This paper is focused on the role of reactive oxygen species produced by neutrophils in the initiation of lipid peroxidation. The oxidation of lipids is considered as a typical hallmark of chronic and acute inflammatory processes. On the other hand the oxidation of biologically active pro-inflammatory lipids could have anti-inflammatory effects and over all contribute to termination of inflammatory process. Therefore, lipid peroxidation mediated by reactive intermediates produced by neutrophils could both potentiate and reduce inflammatory reaction. Necessity of fine balance of these processes can be suggested for proper control of physiological inflammatory response. This paper is focused on the role of reactive oxygen species produced by neutrophils in the initiation of lipid peroxidation. The oxidation of lipids is considered as a typical hallmark of chronic and acute inflammatory processes. On the other hand the oxidation of biologically active pro-inflammatory lipids could have anti-inflammatory effects and over all contribute to termination of inflammatory process. Therefore, lipid peroxidation mediated by reactive intermediates produced by neutrophils could both potentiate and reduce inflammatory reaction. Necessity of fine balance of these processes can be suggested for proper control of physiological inflammatory response. (en)
Title	Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism (en) Oxidanty produkované neutrofily jako modulátory metabolismu vysoce nenasycených mastných kyselin (cs)
skos:prefLabel	Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism (en) Oxidanty produkované neutrofily jako modulátory metabolismu vysoce nenasycených mastných kyselin (cs)
skos:notation	RIV/68081707:_____/08:00309795!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA524/06/1197), P(GA525/06/1196), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Lojek, Antonín Kubala, Lukáš
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	382469
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00309795
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phagocytes; reactive oxygen species; inflammation (en)
http://linked.open.../riv/klicoveSlovo	inflammation reactive oxygen species phagocytes
http://linked.open...ontrolniKodProRIV	[B3B4AC4C76AC]
http://linked.open...i/riv/mistoVydani	Heidelberg
http://linked.open...i/riv/nazevZdroje	Oxidants in biology. A question of balance
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	328 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application The use of terrestrial luminescent bacteria in ecotoxicology Role of free radicals in the regulation of lung inflammation induced by acute and chronic exposure to endotoxin
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Lojek, Antonín
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-1-4020-8398-3
is http://linked.open...avai/riv/vysledek of	Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism

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