About: Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The FHC (fetal human cells) cell line has been established from normal fetal colonic mucosa. Detailed characterization of this cell line and mechanism of spontaneously acquired immortality have not been described yet. Therefore, we characterized the FHC cell line in terms of its tumorigenicity, cytogenetics, and TP53 gene mutation analysis. FHC cells displayed capability for anchorage-independent growth in semisolid media in vitro and formed solid tumors after transplantation into SCID (severe combined immunodeficiency) mice. This tumorigenic phenotype was associated with hypotriploidy and chromosome number ranging from 66 to 69. We identified mutation of TP53 gene in codon 273; triplet CGT coding Arg was changed to CAG coding His. Because of their origin from normal fetal colon and their relative resistance to the induction of apoptosis, FHC cells can be considered a valuable experimental model for various studies. The FHC (fetal human cells) cell line has been established from normal fetal colonic mucosa. Detailed characterization of this cell line and mechanism of spontaneously acquired immortality have not been described yet. Therefore, we characterized the FHC cell line in terms of its tumorigenicity, cytogenetics, and TP53 gene mutation analysis. FHC cells displayed capability for anchorage-independent growth in semisolid media in vitro and formed solid tumors after transplantation into SCID (severe combined immunodeficiency) mice. This tumorigenic phenotype was associated with hypotriploidy and chromosome number ranging from 66 to 69. We identified mutation of TP53 gene in codon 273; triplet CGT coding Arg was changed to CAG coding His. Because of their origin from normal fetal colon and their relative resistance to the induction of apoptosis, FHC cells can be considered a valuable experimental model for various studies. (en)
Title	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation (en)
skos:prefLabel	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation (en)
skos:notation	RIV/68081707:_____/10:00391590!RIV13-MZ0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA204/07/0834), P(GA204/08/1560), P(ME 919), P(NS9600), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pernicová, Zuzana Gajdušková, Pavla Kozubík, Alois Hofmanová, Jiřina Kočí, Lenka Hýžďalová, Martina Souček, Karel Brázdová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	259026
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00391590
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colon epithelial cells; TP53; MYC (en)
http://linked.open.../riv/klicoveSlovo	TP53 colon epithelial cells MYC
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[76BAFCD9FFC3]
http://linked.open...i/riv/nazevZdroje	Cancer Genetics and Cytogenetics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application Possibilities in modulation of neuroendocrine differentiation and progression of prostate cancer. In vitro and in silico identification of non-canonical DNA structures in genomic DNA sequences http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20919 Role of transforming growth factor-beta in regulation of proliferation, differentiation and apoptosis in prostate and colon cancer
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	197
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Hofmanová, Jiřina Kozubík, Alois Pernicová, Zuzana Souček, Karel Hýžďalová, Martina Kočí, Lenka Hajdúch, M. Gajdušková, Pavla Lentvorská, L. Trojanec, R. Vydra, D.
http://linked.open...ain/vavai/riv/wos	000279974200002
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0165-4608
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cancergencyto.2009.11.009
is http://linked.open...avai/riv/vysledek of	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation

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