About: Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines

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Description	Understanding the specific mechanisms modulating cell cycle effect is necessary for defining the mode of action of LA-12. Therefore, the present study aimed to characterize the effect of LA-12, as compared to cisplatin, on cell cycle modulation and the changes in protein expression levels of cell cycle regulatory proteins (cyclin A, cyclin B1, cdk-2), p53 target genes controlling cell cycle (p21waf1/cip1, Gadd45alpha), apoptosis (Bax), DNA repair (Gadd45alpha), and regulation of p53 stability (Mdm-2) in A2780 (parent, cisplatin sensitive) and A2780cis (cisplatin resistant) ovarian carcinoma cell lines. Understanding the specific mechanisms modulating cell cycle effect is necessary for defining the mode of action of LA-12. Therefore, the present study aimed to characterize the effect of LA-12, as compared to cisplatin, on cell cycle modulation and the changes in protein expression levels of cell cycle regulatory proteins (cyclin A, cyclin B1, cdk-2), p53 target genes controlling cell cycle (p21waf1/cip1, Gadd45alpha), apoptosis (Bax), DNA repair (Gadd45alpha), and regulation of p53 stability (Mdm-2) in A2780 (parent, cisplatin sensitive) and A2780cis (cisplatin resistant) ovarian carcinoma cell lines. (en) Tato práce je zaměřená na charakterizaci a studium a porovnání efektů LA-12 a cisplatiny na modulaci buněčného cyklu a změny v expresi proteinů regulujících buněčný cyklus (cyklin A, cyklin B1, cdk-2), p53 cílových genů kontrolujících průchod buněčným cyklem (p21waf1/cip1, Gadd45alpha), apoptózu (Bax), opravu DNA (Gadd45alpha), a regulaci stability p53 (Mdm-2) v buněčných ovariálních buněčných liniích A2780 (parentální, citlivá k cisplatině) a A2780cis (se získanou rezistencí k cisplatině). (cs)
Title	Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines Rozdíly v regulaci buněčného cyklu po ovlivnění ovariálních nádorových buněk platinovými deriváty (cs) Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines (en)
skos:prefLabel	Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines Rozdíly v regulaci buněčného cyklu po ovlivnění ovariálních nádorových buněk platinovými deriváty (cs) Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines (en)
skos:notation	RIV/68081707:_____/06:00039222!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	383;384
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(PZ-Z2/29), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Horváth, Viktor Souček, Karel Švihálková-Šindler, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	471612
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00039222
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ovarian cancer; cell cycle; cisplatin (en)
http://linked.open.../riv/klicoveSlovo	cisplatin ovarian cancer cell cycle
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3F85BAC42F87]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application New Drugs for Cancer Therapy.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	100
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Horváth, Viktor Kozubík, Alois Souček, Karel Sova, P. Šindlerová, Lenka
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0009-2770
number of pages	2 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines Differences in cell cycle regulation after platinum derivatives treatment in sensitive and cisplatin resistant ovarian cancer cell lines

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