About: The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ukázali jsme, že TNF-alfa potlačuje diferenciaci a zesiluje buněčnou smrt navozenou butyrátem (NaBt) u buněk adenokarcinomu (HT-29) i fetálních buněk (FHC) lidského tlustého střeva, a dále jsme studovali úlohu aktivace NF-kappaB během spolupůsobení TNf-alfa a NaBt. TNF-alfa indukovalo rychlou aktivaci Nf-kappaB u obou buněčných linií a tento efekt byl u použitých linií rozdílně modulován účinkem NaBt. Také jsme zjistili rozdílnou odpověď HT-29 a FHC buněk při použití NF-kappaB inhibitoru parthenolidu. (cs) We demonstrated that TNF-alpha suppressed differentiation and potentiated cell death induced by butyrate (NaBt) in both adenocarcinoma HT-29 and fetal FHC human colon cells, and we studied the role of NF-kappaB activation during the TNF-alpha and NaBt co-treatment. TNF-alpha induced rapid NF-kappaB activation in both cell lines and this effect was differently modulated by NaBt in these two cell lines. We also detected a different response of HT-29 and FHC cells to the pre-treatment with the NF-kappaB inhibitor parthenolide. We demonstrated that TNF-alpha suppressed differentiation and potentiated cell death induced by butyrate (NaBt) in both adenocarcinoma HT-29 and fetal FHC human colon cells, and we studied the role of NF-kappaB activation during the TNF-alpha and NaBt co-treatment. TNF-alpha induced rapid NF-kappaB activation in both cell lines and this effect was differently modulated by NaBt in these two cell lines. We also detected a different response of HT-29 and FHC cells to the pre-treatment with the NF-kappaB inhibitor parthenolide. (en)
Title	The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation (en) Interakce butyrátu s TNF-alfa během diferenciace a apoptózy epiteliálních buněk kolonu: Úloha aktivace NF-kappaB (cs)
skos:prefLabel	The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation (en) Interakce butyrátu s TNF-alfa během diferenciace a apoptózy epiteliálních buněk kolonu: Úloha aktivace NF-kappaB (cs)
skos:notation	RIV/68081707:_____/08:00313449!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA524/07/1178), P(KJB500040508), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Vaculová, Alena Hýžďalová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	372802
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00313449
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	butyrate; TNF-alpha; differentiation (en)
http://linked.open.../riv/klicoveSlovo	butyrate TNF-alpha differentiation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DC94C160B4AE]
http://linked.open...i/riv/nazevZdroje	Cytokine
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application Importance of cell lipid changes during differentiation and apoptosis of colon epithelial cells Cell adhesion and anoikis of intestinal cells - the role of TNF family members, AA metabolism, and differentiation
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Vaculová, Alena Hýžďalová, Martina Pacherník, J.
http://linked.open...ain/vavai/riv/wos	000260700600007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1043-4666
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: Role of NF-kappaB activation

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