About: The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study we demonstrated that the structural properties of H1-antihistamines, particularly lipophilicity, significantly affect the biological activity of macrophages. These drugs are able to modulate NO production in vitro by macrophage cell line RAW 264.7 stimulated by LPS. The modulation shown in this study could be caused by the downregulation of iNOS protein expression or by iNOS enzyme activity. In this study we demonstrated that the structural properties of H1-antihistamines, particularly lipophilicity, significantly affect the biological activity of macrophages. These drugs are able to modulate NO production in vitro by macrophage cell line RAW 264.7 stimulated by LPS. The modulation shown in this study could be caused by the downregulation of iNOS protein expression or by iNOS enzyme activity. (en)
Title	The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity (en)
skos:prefLabel	The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity (en)
skos:notation	RIV/68081707:_____/09:00327220!RIV10-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA525/06/1196), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	7-8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Moravcová, Jana Lojek, Antonín Pekarová, Michaela Kubala, Lukáš Číž, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	312404
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/09:00327220
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	H1-antihistamines; nitric oxide; inducible nitric oxide synthase (en)
http://linked.open.../riv/klicoveSlovo	nitric oxide inducible nitric oxide synthase H1-antihistamines
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[29FA3A99A57D]
http://linked.open...i/riv/nazevZdroje	International Immunopharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application The use of terrestrial luminescent bacteria in ecotoxicology
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Lojek, Antonín Pekarová, Michaela Králová, Jana Jančinová, V. Číž, Milan Nosál, R. Račková, L.
http://linked.open...ain/vavai/riv/wos	000267444800026
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1567-5769
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity

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