About: Oncoproteomics Centre

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=LC07017
Description	The aim of proposed research program concerns the proteomic profiling of cancer cell with a perspective towards a new diagnostic and treatment modalities, particularly individualized/personalized therapy and targeted therapy of tumors and their complications. The main topics of interest involve the modulation of gene expression, induction of multidrug resistance, proteomic signatures of anticancer drugs in treated cancer cells, diagnostic, prognostic and predictive significance of selected genes in tumors or patient populations and developments of novel methods for identification of tumor-drug interactions. Oncoproteomics Centre - research consortium of recognized national research and clinical centers will also contribute to the strengthening of translational research with direct impacts on quality of life, creation of intellectual property, employment of young and gifted scientists and finally to increased quality of regional research in both national and international context. (en) Cílem projektu je s pomocí proteomického profilování identifikovat nové cíle pro léčiva, diagnostické, prognostické a prediktivní markery nádorových onemocnění, zlepšit možnosti výchovy studentů a posílit národní translační proteomický výzkum.
Title	Oncoproteomics Centre (en) Centrum nádorové proteomiky
skos:notation	LC07017
http://linked.open...avai/cep/aktivita	Basic Research Centres
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/LC07017/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/LC07017/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91883901
http://linked.open...ai/cep/hlavniObor	FD - Onkologie a hematologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	proteome; proteomics; posttranslational modifications; biomedicine; cancer biology; gene expression; diagnostics; prognostic and predictive marker; therapeutic targets; multi-drug resistance; cytoprotection; cytotoxicity; cell cycle; cell metabolism (en)
http://linked.open...ep/partnetrHlavni	Lékařská fakulta
http://linked.open...inujicichPrijemcu	1 (xsd:int)
http://linked.open...cep/pocetPrijemcu	3 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	86 (xsd:int)
http://linked.open...enychVysledkuVRIV	86 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-02-10 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/428%2F2010-31
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SMSM200700LC3
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CB - Analytická chemie, separace CE - Biochemie
http://linked.open...ep/zahajeniReseni	2007-04-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Within the Center, we made significant progress particularly in the characterization of molecular mechanisms of action/drug resistance of anticancer drugs, biomarkers, the study of Pseudallescheria sp. proteome and introduction of new proteomic methods based on mass spectrometry. We have also organized international conferences(DDPEO, CEEPC), workshops and symposia of national significancance. (en) V rámci Centra se nám podařilo dosáhnout významného pokroku zejména v oblasti charakterizace molekulárních účinků a mechanismů rezistence nových protinádorových léčiv, biomarkerů, v oblasti toxikologie hub řádu Pseudallescheria a ve vývoji nových metod hmotnostní spetkrometrie. S pomocí Centra byly organizovány mezinárodní konference DDPEO a CEEPC a také semináře a konference místního významu. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	proteome biomedicine cell cycle cytotoxicity diagnostics gene expression proteomics cancer biology cytoprotection multi-drug resistance posttranslational modifications prognostic and predictive marker therapeutic targets
is http://linked.open...vavai/riv/projekt of	Challenges in cancer research and multifaceted approaches for cancer biomarker quest In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome Effect of anti-cancer drug cis-platin on leukemia cells-protein profiling using three independent analytical techniques Multivariate statistical analysis for anti-cancer drug treatment evaluation Proteome of leukaemic cells after cisplatin treatment - comparison of three independent analytical techniques - Hydroxylated Anthraquinones Produced by Geosmithia species Biomarkers of Aspergillus spores: Strain typing and protein identification Stress Proteins in the Cytoplasmic Membrane Fraction of Bacillus subtilis Dissociation of nystatin and amphotericin analogues: characterisation of minor anti-fungal macrolides Comparative protein profiles: Potential molecular markers from spermatozoa of Acipenseriformes (Chondrostei, Pisces) Fungal Metabolites for Microorganism Classification by Mass Spectrometry Molecular characterization of the iron binding protein ferritin in Eisenia andrei earthworms MSTools-Web based application for visualization and presentation of HXMS data Scedosporium and Pseudallescheria low molecular weight metabolites revealed by database search Reproductive tissue expression and sperm localization of porcine beta-microseminoprotein Spatial Distribution of Glycerophospholipids in the Ocular Lens Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) Cancer cell response to anthracyclines effects: Mysteries of the hidden proteins associated with these drugs Cyclin-dependent kinase inhibitors and cancer: usefulness of proteomic approaches in assesment of the molecular mechanisms and efficacy of novel therapeutics. Desorpční elektrosprej: Moderní metoda analýzy organických povrchů Determination of sibiromycin and its natural derivatives using new analytical and structural approaches Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy Challenges in cancer research and multifaceted approaches for cancer qPCR detection system for R462Q (G>A) polymorphism of RNAseL gene. INTRAMEDULLARY SPINAL CORD AND CAUDA EQUINA METASTASIS OF BREAST CARCINOMA: CASE REPORT The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors Characterization of Pseudacyclins A-E, a Suite of Cyclic Peptides Produced Pseudallescheria boydii Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemicsl stability display prolonged circulation and remain intact in the blood of mice Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy The Psb27 Assembly Factor Binds to the CP43 Complex of Photosystem II in the Cyanobacterium Synechocystis sp PCC 6803 The 14-3-3 Protein Interactome: Interactions of the N-Termini Dimer Interface for Both Homodimer and Heterodimer After the Tyrosine Hydroxylase Binding A multiprotein binding interface in an intrinsically disordered region of the tumour suppressor protein Interferon Regulatory Factor-1 A new approach to the isolation and characterization of wheat flour allergens DnaK and GroEL chaperones are recruited to the Bacillus subtilis membrane after short-term ethanol stress Proteomic analysis of wheat proteins recognized by IgE antibodies of allergic patients Claviceps nigricans and Claviceps grohii: their alkaloids and phylogenetic placement Liquid chromatography-tandem mass spectrometry characterization of ergocristam degradation products Characterization of DESI-FTICR mass spectrometry – from ECD to accurate mass tissue analysis Application of Fungal Cyclic Peptides and Metabolites Proteomic analysis uncovers a metabolic phenotype in C. elegans after Současné trendy hmotnostní spektrometrie Cyclosporins from Mycelium sterilae MS 2929 Magnesium interference and different efficiencies of diastereoisomeric cluster formation in phenylalanine enantiomeric discrimination by the kinetic method Modified electrophoretic and digestion conditions allow a simplified mass spectrometric evaluation of disulfide bonds Utilization of high-accuracy FTICR-MS data in protein quantitation experiments Hepcidin, the Hormone of Iron Metabolism, is Bound Specifically to a-2-Macroglobulin

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