About: Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The egg protein ovalbumin (OVA) belongs to six most frequent food allergens. We investigated how thermal processing influences its ability to induce allergic symptoms and immune responses in mouse model of food allergy. Effect of increased temperature (70 degrees C and 95 degrees C) on OVA secondary structure was characterized by circular dichroism and by the kinetics of pepsin digestion with subsequent HPLC. BALB/c mice were sensitized intraperitoneally and challenged with repeated gavages of OVA or OVA heated to 70 degrees C (h-OVA). Levels of allergen-specific serum antibodies were determined by ELISA (IgA and IgGs) or by beta-hexosaminidase release test (IgE). The egg protein ovalbumin (OVA) belongs to six most frequent food allergens. We investigated how thermal processing influences its ability to induce allergic symptoms and immune responses in mouse model of food allergy. Effect of increased temperature (70 degrees C and 95 degrees C) on OVA secondary structure was characterized by circular dichroism and by the kinetics of pepsin digestion with subsequent HPLC. BALB/c mice were sensitized intraperitoneally and challenged with repeated gavages of OVA or OVA heated to 70 degrees C (h-OVA). Levels of allergen-specific serum antibodies were determined by ELISA (IgA and IgGs) or by beta-hexosaminidase release test (IgE). (en)
Title	Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy (en)
skos:prefLabel	Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy (en)
skos:notation	RIV/61388971:_____/12:00378866!RIV13-GA0-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06155), P(GA310/07/0414), P(GD310/08/H077), P(IAA500200710), P(IAA500200801), P(KJB500200904), P(LC07017), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šrůtková, Dagmar Kozáková, Hana Schwarzer, Martin Šotkovský, Petr Tučková, Ludmila Goliáš, Jaroslav Palová-Jelínková, Lenka Kverka, Miloslav Klimešová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	138749
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/12:00378866
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BRUSH-BORDER MEMBRANES; BIRCH POLLEN ALLERGEN; MURINE MODEL (en)
http://linked.open.../riv/klicoveSlovo	BIRCH POLLEN ALLERGEN BRUSH-BORDER MEMBRANES MURINE MODEL
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0F5AF0E32CE6]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of antiinflammatory properties of selected substances of bacterial and plant origin in experimental colitis therapy and prevention Identification of new markers for molecular diagnosis of inflammatory and tumor diseases. The role of innate and adaptive immunity in development of gluten-sensitive entheropathy Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches Food allergy to wheat proteins Oncoproteomics Centre Effect of probiotic lactobacilli on the development of allergy in an experimental model of human disease
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Goliáš, Jaroslav Tučková, Ludmila Šotkovský, Petr Kozáková, Hana Schwarzer, Martin Šrůtková, Dagmar Palová-Jelínková, Lenka Klimešová, Klára Kverka, Miloslav Ferreira, F. Wallner, M.
http://linked.open...ain/vavai/riv/wos	000305343100015
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	1932-6203
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0037156
is http://linked.open...avai/riv/vysledek of	Heat-Induced Structural Changes Affect OVA-Antigen Processing and Reduce Allergic Response in Mouse Model of Food Allergy

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