About: Epidermal Growth Factor Receptor

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Epidermal Growth Factor Receptor
equivalentClass	nodeID://b632327
OMIM_Number	131550
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme Receptor
Preferred_Name	Epidermal Growth Factor Receptor
UMLS_CUI	C0034802
ALT_DEFINITION	The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor.NCI-GLOSS
Legacy_Concept_Name	Epidermal_Growth_Factor_Receptor
FULL_SYN	EC 2.7.10.1SYNCI Epidermal Growth Factor ReceptorPTNCI Proto-Oncogene c-erbB-1SYNCI ERBB ProteinSYNCI EGF ReceptorSYNCI HER1PTNCI-GLOSSCDR0000044399 EGFRPTNCI-GLOSSCDR0000044397 ErbB1PTNCI-GLOSSCDR0000044398 epidermal growth factor receptorPTNCI-GLOSSCDR0000045680 EGFRSYNCI Epidermal Growth Factor Receptor Protein-Tyrosine KinaseSYNCI erbB-1SYNCI Receptor Tyrosine-Protein Kinase erbB-1SYNCI c-erbB-1SYNCI Urogastrone ReceptorSYNCI
Swiss_Prot	P00533
DEFINITION	Epidermal growth factor receptor (1210 aa, ~134 kDa) is encoded by the human EGFR gene. This protein plays a role in cell-cell adhesion, cell migration, cell proliferation and signal transduction.NCI
DesignNote	The Epidermal Growth Factor Receptor is a protein tyrosine kinase with two glycoprotein components of different molecular weight; both contain phosphotyrosine and phosphothreonine but only the higher molecular weight form contains phosphoserine. The tyrosine kinase activity is required for internalization or degradation of EGF-EGFR receptor complexes. EGF stimulation of the receptor initiates DNA and protein synthesis in target cells. The receptor is not found on mitotically quiescent cells except the stomach where it controls synthesis and release of digestive enzymes and gastric acid. TGF alpha also binds to and activates the receptor.
code	C17068
sameAs	Receptor, Epidermal Growth Factor
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0018582
is someValuesFrom of	nodeID://b643458 nodeID://b644685 nodeID://b648730 nodeID://b658688 nodeID://b670731 nodeID://b676610 nodeID://b724130
is Has_Target of	Suramin Sodium Indium In 111 Chimeric Monoclonal Antibody 806 Zalutumumab Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806 CETUXIMAB GEFITINIB Canertinib Dihydrochloride LAPATINIB Erlotinib Hydrochloride Pelitinib Multitargeted Tyrosine Kinase Inhibitor XL647 Varlitinib EGFR/HER2 Inhibitor AV-412 Lapatinib Ditosylate Fluorine F 18 FEQA Afatinib Varlitinib Tosylate Afatinib Dimaleate
is sameAs of	Receptor, Epidermal Growth Factor

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