About: Suramin Sodium

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Suramin Sodium
rdfs:subClassOf	Angiogenesis Activator Inhibitor nodeID://b716389 nodeID://b716390 nodeID://b716391 nodeID://b716392 nodeID://b716393 nodeID://b716394
Has_Free_Acid_Or_Base_Form	Suramin
Has_Target	Receptor, Epidermal Growth Factor Receptors, Vascular Endothelial Growth Factor Receptors, Platelet-Derived Growth Factor Heparin Binding Growth Factor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Suramin Sodium
NSC_Code	34936
UMLS_CUI	C0813205
CAS_Registry	129-46-4
Accepted_Therapeutic_Use_For	African trypanosomiasis; onchocerciasis
In_Clinical_Trial_For	Bladder cancer; breast cancer; non-small cell lung cancer
FDA_UNII_Code	89521262IH
Contributing_Source	FDA
Chemical_Formula	C51H34N6O23S6.6Na
Legacy_Concept_Name	Suramin_Sodium
FULL_SYN	Fourneau 309SYDTPNSC0034936 309 FSYDTPNSC0034936 Fourneau 309FBNCI 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium SaltSNNCI SURAMIN SODIUMPTFDA89521262IH Suramin HexasodiumPTDCP30140 Suramin SodiumPTNCI Sodium SuraminSYNCI Sodium suraminSYDTPNSC0034936 Suramin sodiumSYDTPNSC0034936 NaganinSYDTPNSC0034936 NaganolSYDTPNSC0034936 MoranylSYDTPNSC0034936 309 FFBNCI GermaninSYDTPNSC0034936 AntrypolSYDTPNSC0034936 Bayer 205SYDTPNSC0034936 CI-1003CNNCI Suramin HexasodiumSYNCI NaganinFBNCI NaganolFBNCI MetaretBRNCI MoranylFBNCI BelganylFBNCI GermaninFBNCI AntrypolFBNCI Bayer 205CNNCI NaganinumFBNCI NaphurideFBNCI
DEFINITION	A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.NCI
code	C1848
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0329624
is Has_Salt_Form of	Suramin

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