About: Vascular Endothelial Growth Factor Receptor

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About: Vascular Endothelial Growth Factor Receptor Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vascular Endothelial Growth Factor Receptor
rdfs:subClassOf	Receptors, Growth Factor nodeID://b722805
Semantic_Type	Amino Acid, Peptide, or Protein Receptor
Preferred_Name	Vascular Endothelial Growth Factor Receptor
UMLS_CUI	C0148199
Legacy_Concept_Name	Vascular_Endothelial_Growth_Factor_Receptor
FULL_SYN	VEGFRSYNCI Vascular Endothelial Growth Factor ReceptorPTNCI Receptor, Vascular Endothelial Growth FactorSYNCI
DEFINITION	There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor.NCISemin Thromb Hemost 2000;26(5):561-9
code	C17293
sameAs	Receptors, Vascular Endothelial Growth Factor
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0185203
is rdf:first of	nodeID://b729567 nodeID://b729568 nodeID://b729569
is someValuesFrom of	nodeID://b643528 nodeID://b711337
is Has_Target of	Suramin Sodium AFLIBERCEPT Pazopanib Hydrochloride Dovitinib Lactate Multitargeted Tyrosine Kinase Inhibitor XL647 PAZOPANIB Dovitinib Lactate Anhydrous
is sameAs of	Receptors, Vascular Endothelial Growth Factor

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