About: Dovitinib Lactate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dovitinib Lactate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dovitinib Lactate
UMLS_CUI
  • C1568328
CAS_Registry
  • 915769-50-5
FDA_UNII_Code
  • 69VKY8P7EA
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 488976
PDQ_Closed_Trial_Search_ID
  • 488976
Chemical_Formula
  • C21H21FN6O.C3H6O3.H2O
Legacy_Concept_Name
  • CHIR-258
FULL_SYN
  • 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one mono 2-hydroxypropanoate HydrateSNNCI
  • Dovitinib LactatePTNCI
  • TKI258CNNCI
  • DOVITINIB LACTATEPTFDA69VKY8P7EA
  • CHIR-258CNNCI
  • RTK Inhibitor TKI258SYNCI
DEFINITION
  • The orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.NCI
code
  • C62435
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