About: Dovitinib Lactate

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About: Dovitinib Lactate Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Dovitinib Lactate
rdfs:subClassOf	Tyrosine Kinase Inhibitor
Has_Free_Acid_Or_Base_Form	Dovitinib
Has_Target	Receptors, Vascular Endothelial Growth Factor Receptors, Platelet-Derived Growth Factor Receptor, Fibroblast Growth Factor, Type 3 Fms-Related Tyrosine Kinase 3
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Dovitinib Lactate
UMLS_CUI	C1568328
CAS_Registry	915769-50-5
FDA_UNII_Code	69VKY8P7EA
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	488976
PDQ_Closed_Trial_Search_ID	488976
Chemical_Formula	C21H21FN6O.C3H6O3.H2O
Legacy_Concept_Name	CHIR-258
FULL_SYN	4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one mono 2-hydroxypropanoate HydrateSNNCI Dovitinib LactatePTNCI TKI258CNNCI DOVITINIB LACTATEPTFDA69VKY8P7EA CHIR-258CNNCI RTK Inhibitor TKI258SYNCI
DEFINITION	The orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.NCI
code	C62435
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0517294
is Has_Salt_Form of	Dovitinib

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