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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Suramin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Suramin
UMLS_CUI
  • C0038880
CAS_Registry
  • 145-63-1
Accepted_Therapeutic_Use_For
  • Trypanosomiasis; hormone-refractory prostate cancer
In_Clinical_Trial_For
  • Bladder cancer; Breast cancer; Non-small cell lung cancer; Renal cell cancer
FDA_UNII_Code
  • 6032D45BEM
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40052
PDQ_Closed_Trial_Search_ID
  • 40052
Chemical_Formula
  • C51H40N6O23S6
Legacy_Concept_Name
  • Suramin
CHEBI_ID
  • CHEBI:45906
FULL_SYN
  • SURAMINPTFDA6032D45BEM
  • suraminPTNCI-GLOSSCDR0000045271
  • SuraminPTNCI
DEFINITION
  • A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)NCI
code
  • C853
sameAs
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